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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F11%3A00009377%21RIV12-MZ0-75010330
rdf:type
n3:Vysledek skos:Concept
dcterms:description
In this study, we described the first finding of a KPC-2-producing strain of Klebsiella pneumoniae, which was isolated from a surgical wound swab, decubitus ulcer, and urine of a patient previously hospitalized in Greece. The patient underwent various antibiotic therapies including a colistin treatment. However, after approximately 20 days of the colistin therapy, the strain developed a high-level resistance to this drug. All the isolates were indistinguishable by pulsed field gel electrophoretic analysis and belonged to the international clone ST258, which is typical of KPC-producing K. pneumoniae isolates. The bla (KPC-2) gene was located on a Tn4401a transposon variant. The OmpK35 and OmpK36 genes analysis performed due to the high resistance level of the strains to beta-lactams exhibited no changes in their sequence or in their expression when compared with carbapenem-susceptible isolates. In this study, we described the first finding of a KPC-2-producing strain of Klebsiella pneumoniae, which was isolated from a surgical wound swab, decubitus ulcer, and urine of a patient previously hospitalized in Greece. The patient underwent various antibiotic therapies including a colistin treatment. However, after approximately 20 days of the colistin therapy, the strain developed a high-level resistance to this drug. All the isolates were indistinguishable by pulsed field gel electrophoretic analysis and belonged to the international clone ST258, which is typical of KPC-producing K. pneumoniae isolates. The bla (KPC-2) gene was located on a Tn4401a transposon variant. The OmpK35 and OmpK36 genes analysis performed due to the high resistance level of the strains to beta-lactams exhibited no changes in their sequence or in their expression when compared with carbapenem-susceptible isolates.
dcterms:title
KPC-2-producing Klebsiella pneumoniae isolated from a Czech patient previously hospitalized in Greece and in vivo selection of colistin resistance KPC-2-producing Klebsiella pneumoniae isolated from a Czech patient previously hospitalized in Greece and in vivo selection of colistin resistance
skos:prefLabel
KPC-2-producing Klebsiella pneumoniae isolated from a Czech patient previously hospitalized in Greece and in vivo selection of colistin resistance KPC-2-producing Klebsiella pneumoniae isolated from a Czech patient previously hospitalized in Greece and in vivo selection of colistin resistance
skos:notation
RIV/75010330:_____/11:00009377!RIV12-MZ0-75010330
n3:predkladatel
n8:ico%3A75010330
n4:aktivita
n10:P
n4:aktivity
P(NS9717)
n4:cisloPeriodika
4
n4:dodaniDat
n16:2012
n4:domaciTvurceVysledku
n7:9090010 n7:3101169 n7:5976405
n4:druhVysledku
n11:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
208318
n4:idVysledku
RIV/75010330:_____/11:00009377
n4:jazykVysledku
n9:eng
n4:klicovaSlova
Klebsiella pneumoniae; colistin; rezistance
n4:klicoveSlovo
n5:Klebsiella%20pneumoniae n5:rezistance n5:colistin
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[A429FB0833C4]
n4:nazevZdroje
Folia microbiologica
n4:obor
n15:EE
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
8
n4:projekt
n17:NS9717
n4:rokUplatneniVysledku
n16:2011
n4:svazekPeriodika
56
n4:tvurceVysledku
Hrabák, J. Niemczykova, J. Studentová, V. Červená, D. Urbášková, Pavla Chudáčková, E. Fridrichová, Marta Žemličková, Helena
n4:wos
000294012800012
s:issn
0015-5632
s:numberOfPages
5