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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F11%3A00009337%21RIV12-MZ0-75010330
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Dichloromethane and iodomethane are colorless relatively volatile liquids, which are used as solvents in chemical manufacturing processes. The major route of exposure is via inhalation and to a lesser extent through the skin and digestive tract. Both substances are characterized by significant neurotoxic effects. A 37-year-old chemist subjected to long-term inhalation exposure to both substances had been experiencing headaches, dizziness and fatigue for about 5 years. Magnetic resonance imaging )MRI( of his brain in the acute state demonstrated the presence of a T2-hyperintense lesion in the splenium of the corpus callosum, suggestive as myelinolysis. On MRI 16 days later, the MRI changes had completely resolved and the clinical picture had improved significantly. To the best of our knowledge, this is the first published report of a case of %22reversible focal splenial lesion syndrome of the corpus callosum%22, which was likely caused by industrial toxic substances. Dichloromethane and iodomethane are colorless relatively volatile liquids, which are used as solvents in chemical manufacturing processes. The major route of exposure is via inhalation and to a lesser extent through the skin and digestive tract. Both substances are characterized by significant neurotoxic effects. A 37-year-old chemist subjected to long-term inhalation exposure to both substances had been experiencing headaches, dizziness and fatigue for about 5 years. Magnetic resonance imaging )MRI( of his brain in the acute state demonstrated the presence of a T2-hyperintense lesion in the splenium of the corpus callosum, suggestive as myelinolysis. On MRI 16 days later, the MRI changes had completely resolved and the clinical picture had improved significantly. To the best of our knowledge, this is the first published report of a case of %22reversible focal splenial lesion syndrome of the corpus callosum%22, which was likely caused by industrial toxic substances.
dcterms:title
Exposure to iodomethane and dichloromethane associated with a confusional state Exposure to iodomethane and dichloromethane associated with a confusional state
skos:prefLabel
Exposure to iodomethane and dichloromethane associated with a confusional state Exposure to iodomethane and dichloromethane associated with a confusional state
skos:notation
RIV/75010330:_____/11:00009337!RIV12-MZ0-75010330
n9:predkladatel
n10:ico%3A75010330
n3:aktivita
n14:I n14:V
n3:aktivity
I, V
n3:cisloPeriodika
3
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n16:2009412
n3:druhVysledku
n12:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
199004
n3:idVysledku
RIV/75010330:_____/11:00009337
n3:jazykVysledku
n8:eng
n3:klicovaSlova
iodomethane; dichloromethane; intoxication
n3:klicoveSlovo
n5:intoxication n5:dichloromethane n5:iodomethane
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[6D20142093D7]
n3:nazevZdroje
NeuroToxicology
n3:obor
n15:FM
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
32
n3:tvurceVysledku
Urban, Pavel Latta, J. Eichlerová, A. Mrklovský, M. Ehler, E.
n3:wos
000289925800003
s:issn
0161-813X
s:numberOfPages
5