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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F10%3A00008907%21RIV11-MZ0-75010330
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity. Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity.
dcterms:title
Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data
skos:prefLabel
Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data
skos:notation
RIV/75010330:_____/10:00008907!RIV11-MZ0-75010330
n3:aktivita
n11:V
n3:aktivity
V
n3:cisloPeriodika
2
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n5:7955332 n5:8964297 n5:9962999
n3:druhVysledku
n13:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
251452
n3:idVysledku
RIV/75010330:_____/10:00008907
n3:jazykVysledku
n14:eng
n3:klicovaSlova
skin irritation; skin; human epidermal model
n3:klicoveSlovo
n10:skin n10:human%20epidermal%20model n10:skin%20irritation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[23590950B307]
n3:nazevZdroje
Contact dermatitis
n3:obor
n16:FM
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
62
n3:tvurceVysledku
Bendová, Hana Jírová, Dagmar Marriott, M. Liebsch, M. Kejlová, Kristina Basketter, D. Kandárová, H.
n3:wos
000274167800006
s:issn
0105-1873
s:numberOfPages
8