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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F10%3A00008887%21RIV13-GA0-75010330
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls. Three software tools successfully pointed to the overrepresentation of genes related to the mitogen-activated protein kinase (MAPK) signalling pathways among the 1340 most strongly associated markers from the GWAS (allelic P value 10)-3)). The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events (P-trend = 2.2 x 10(-16), ORper allele = 1.34, 95% CI 1.11-1.61). Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls. Three software tools successfully pointed to the overrepresentation of genes related to the mitogen-activated protein kinase (MAPK) signalling pathways among the 1340 most strongly associated markers from the GWAS (allelic P value 10)-3)). The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events (P-trend = 2.2 x 10(-16), ORper allele = 1.34, 95% CI 1.11-1.61).
dcterms:title
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
skos:prefLabel
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
skos:notation
RIV/75010330:_____/10:00008887!RIV13-GA0-75010330
n4:aktivita
n16:Z n16:P n16:I
n4:aktivity
I, P(GA310/07/1430), Z(AV0Z50390512)
n4:cisloPeriodika
9
n4:dodaniDat
n10:2013
n4:domaciTvurceVysledku
n13:5013690
n4:druhVysledku
n18:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
260474
n4:idVysledku
RIV/75010330:_____/10:00008887
n4:jazykVysledku
n8:eng
n4:klicovaSlova
colon cancer; genetic polymorphisms
n4:klicoveSlovo
n7:genetic%20polymorphisms n7:colon%20cancer
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[D59E02599AEE]
n4:nazevZdroje
Carcinogenesis
n4:obor
n14:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
34
n4:projekt
n11:GA310%2F07%2F1430
n4:rokUplatneniVysledku
n10:2010
n4:svazekPeriodika
31
n4:tvurceVysledku
Gorgens, H. Morak, M. Kunkel, N. Buch, S. Vodičková, Ludmila Goecke, T. Lascorz, J. Engel, C. Weires, M. Holinski-Feder, E. Buttner, R. Steinke, V. Schulmann, K. Hoffmeister, M. Naccarati, A. Chen, B. W. Pardini, B. Forsti, A. Kloor, M. Schackert, H. K. Rahner, N.
n4:wos
000281530400015
n4:zamer
n17:AV0Z50390512
s:issn
0143-3334
s:numberOfPages
8