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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F09%3A00008403%21RIV10-GA0-75010330
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population. Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. We conclude that the I157T and other alterations in its proximity predispose to sporadic but not to familial CRC in the Czech population.
dcterms:title
The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population
skos:prefLabel
The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population
skos:notation
RIV/75010330:_____/09:00008403!RIV10-GA0-75010330
n4:aktivita
n5:Z n5:P
n4:aktivity
P(GA310/07/1430), Z(MSM0021620808)
n4:cisloPeriodika
4
n4:dodaniDat
n8:2010
n4:domaciTvurceVysledku
n11:2537354 n11:4078829
n4:druhVysledku
n15:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
306872
n4:idVysledku
RIV/75010330:_____/09:00008403
n4:jazykVysledku
n9:eng
n4:klicovaSlova
Checkpoint kinase 2 (CHEK2, CHK2); colorectal cancer; germ-line mutation; genetic screening; genetic predisposition; risk assessment
n4:klicoveSlovo
n6:genetic%20predisposition n6:risk%20assessment n6:Checkpoint%20kinase%202%20%28CHEK2 n6:genetic%20screening n6:germ-line%20mutation n6:colorectal%20cancer n6:CHK2%29
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[50D5A774D3F0]
n4:nazevZdroje
European journal of cancer
n4:obor
n16:FD
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
7
n4:projekt
n18:GA310%2F07%2F1430
n4:rokUplatneniVysledku
n8:2009
n4:svazekPeriodika
45
n4:tvurceVysledku
Havránek, O. Hlavatá, Ivona Kleibl, Z. Souček, Pavel Ševčík, J. Novotný, J. Pohlreich, P.
n4:wos
000264606100024
n4:zamer
n13:MSM0021620808
s:issn
0959-8049
s:numberOfPages
7