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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F09%3A00007696%21RIV10-GA0-75010330
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://www.szu.cz/uploads/documents/CLC/hechlp/JM_Publikace/TDA_TDI_metabolites_in_rat_urine.pdf
dcterms:description
Profiles of the urinary metabolites of 2,4-toluenediisocyanate (2,4-TDI) and 2,4- toluenediamine (2,4-TDA) have been studied in rats with the aim to find suitable biomarkers of 2,4-TDI exposure. The animals were dosed intraperitoneally with 0.10 mmol/kg of each compound. Urine was cleaned-up by the extraction with acetonitrile and by preparative HPLC to remove polar matrix components. The residuum containing a wide range of metabolites was analyzed by HPLC/MS in the APCI ionization mode. Profiles of the urinary metabolites of 2,4-toluenediisocyanate (2,4-TDI) and 2,4- toluenediamine (2,4-TDA) have been studied in rats with the aim to find suitable biomarkers of 2,4-TDI exposure. The animals were dosed intraperitoneally with 0.10 mmol/kg of each compound. Urine was cleaned-up by the extraction with acetonitrile and by preparative HPLC to remove polar matrix components. The residuum containing a wide range of metabolites was analyzed by HPLC/MS in the APCI ionization mode.
dcterms:title
HPLC/MS analysis of the metabolites of 2,4-toluenediamine (2,4-TDA) and 2,4-toluenediisocyanate (2,4-TDI) in rat urine HPLC/MS analysis of the metabolites of 2,4-toluenediamine (2,4-TDA) and 2,4-toluenediisocyanate (2,4-TDI) in rat urine
skos:prefLabel
HPLC/MS analysis of the metabolites of 2,4-toluenediamine (2,4-TDA) and 2,4-toluenediisocyanate (2,4-TDI) in rat urine HPLC/MS analysis of the metabolites of 2,4-toluenediamine (2,4-TDA) and 2,4-toluenediisocyanate (2,4-TDI) in rat urine
skos:notation
RIV/75010330:_____/09:00007696!RIV10-GA0-75010330
n3:aktivita
n8:P
n3:aktivity
P(GA310/00/0934)
n3:dodaniDat
n12:2010
n3:domaciTvurceVysledku
n10:1450522 n10:7637292 n10:5905621
n3:druhVysledku
n14:A
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
317900
n3:idVysledku
RIV/75010330:_____/09:00007696
n3:jazykVysledku
n13:eng
n3:klicovaSlova
2,4-toluendiisocyanate; toluene metabolites; urine
n3:klicoveSlovo
n11:toluene%20metabolites n11:2 n11:urine n11:4-toluendiisocyanate
n3:kodPristupu
n5:V
n3:kontrolniKodProRIV
[481984915666]
n3:obor
n7:FP
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n17:GA310%2F00%2F0934
n3:rokUplatneniVysledku
n12:2009
n3:tvurceVysledku
Chvalová, D. Šmigolová, Pavla Morita, Y. Nohová, Hana Mráz, Jaroslav Sakai, T.