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Statements

Subject Item
n2:RIV%2F70883521%3A28610%2F14%3A43871772%21RIV15-MSM-28610___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0378517314005808
dcterms:description
The aim of this work was to investigate the potential of an amphiphilic system comprising chitosan-grafted polylactide andcarboxyl-functionalized polylactide acid as a carrier for the controlled release and co-release of two DNA alkylating drugs: doxorubicin and temozolomide. Polylactide and carboxyl-functionalized polylactide acid were obtained through direct melt polycondensation reaction, using methanesulfonic acid as a non-toxic initiator, and subsequently these were grafted to the chitosan backbone through a coupling reaction, utilizing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as a condensing agent. ATR-FTIR analysis and conductometric titration confirmed that a reaction between CS and PLA, PLACA2% and PLACA5% occurred. Chitosan-grafted-polylactide and polylactide-citric acid nanoparticles were prepared via the polyelectrolyte complex technique, applying dextran sulphate as a polyanion, and loaded with doxorubicin and temozolomide. The diameter of particles, zeta-potential and their relationship to temperature and pH were analysed in all formulations. Encapsulation, co-encapsulation efficiency and release studies were conducted in different physiological simulated environments and human serum. Results showed the continuous release of drugs without an initial burst in different physiological media. The aim of this work was to investigate the potential of an amphiphilic system comprising chitosan-grafted polylactide andcarboxyl-functionalized polylactide acid as a carrier for the controlled release and co-release of two DNA alkylating drugs: doxorubicin and temozolomide. Polylactide and carboxyl-functionalized polylactide acid were obtained through direct melt polycondensation reaction, using methanesulfonic acid as a non-toxic initiator, and subsequently these were grafted to the chitosan backbone through a coupling reaction, utilizing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as a condensing agent. ATR-FTIR analysis and conductometric titration confirmed that a reaction between CS and PLA, PLACA2% and PLACA5% occurred. Chitosan-grafted-polylactide and polylactide-citric acid nanoparticles were prepared via the polyelectrolyte complex technique, applying dextran sulphate as a polyanion, and loaded with doxorubicin and temozolomide. The diameter of particles, zeta-potential and their relationship to temperature and pH were analysed in all formulations. Encapsulation, co-encapsulation efficiency and release studies were conducted in different physiological simulated environments and human serum. Results showed the continuous release of drugs without an initial burst in different physiological media.
dcterms:title
Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy
skos:prefLabel
Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide co-therapy
skos:notation
RIV/70883521:28610/14:43871772!RIV15-MSM-28610___
n3:aktivita
n13:S n13:P
n3:aktivity
P(ED2.1.00/03.0111), S
n3:cisloPeriodika
1-2
n3:dodaniDat
n17:2015
n3:domaciTvurceVysledku
n15:6339603 Di Martino, Antonio
n3:druhVysledku
n14:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
2356
n3:idVysledku
RIV/70883521:28610/14:43871772
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Polylactide; Chitosan; Temozolomide; Doxorubicin; Drug delivery System; Nanoparticles
n3:klicoveSlovo
n8:Drug%20delivery%20System n8:Nanoparticles n8:Doxorubicin n8:Polylactide n8:Chitosan n8:Temozolomide
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[ED91B990D5B9]
n3:nazevZdroje
International Journal of Pharmaceutics
n3:obor
n4:CD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n11:ED2.1.00%2F03.0111
n3:rokUplatneniVysledku
n17:2014
n3:svazekPeriodika
474
n3:tvurceVysledku
Sedlařík, Vladimír Di Martino, Antonio
n3:wos
000342681700016
s:issn
0378-5173
s:numberOfPages
12
n20:doi
10.1016/j.ijpharm.2014.08.014
n19:organizacniJednotka
28610