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Statements

Subject Item
n2:RIV%2F70883521%3A28610%2F14%3A43871580%21RIV15-MSM-28610___
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://www.cskb.cz/res/file/KBM-pdf/2014/2014-1/KBM-2014-1-Salek-4.pdf
dcterms:description
Objective: The aim of the study is to compare estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcreatinine) and cystatine C (eGFRcystatin C) and to study the impact of these estimations on detection and staging of chronic kidney disease (CKD) in diabetic patients. Design: retrospective cross section design. Settings: Department of clinical biochemistry, Tomas Bata Hospital Inc., Zlín, Czech Republic. Materials and methods: The study population consisted of 565 consecutive diabetic patients from the outpatient diabetic clinic of Tomas Bata Hospital in Zlin in the Czech Republic. Serum creatinine and cystatin C were measured by newly standardized methods and eGFR was calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, which were established in 2012. CKD is defined as GFR below 1.0 ml/s/1.73m2. Results: The mean eGFRcreatinine (1.443 ± 0.014) ml/s/1.73m2 was lower than eGFRcystatin C (1.512 ± 0.017) ml/s/1.73m 2, (p < 0.002). We found poor accordance to identify CKD. The discrepancy was found in 38 patients. Conclusion: Mean eGFRcystatin C was significantly higher than eGFRcreatinine. eGFR cystatin C gives higher values than eGFRcreatinine mainly at eGFR over 1.5 ml/s/1.73m2. Our results support the use of both eGFRcystatin C and eGFRcreatinine +cystatin C in patients with diabetes mellitus without albuminuria or another marker of kidney damage at GFR stages 2 and 3a according to eGFRcreatinine. Objective: The aim of the study is to compare estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcreatinine) and cystatine C (eGFRcystatin C) and to study the impact of these estimations on detection and staging of chronic kidney disease (CKD) in diabetic patients. Design: retrospective cross section design. Settings: Department of clinical biochemistry, Tomas Bata Hospital Inc., Zlín, Czech Republic. Materials and methods: The study population consisted of 565 consecutive diabetic patients from the outpatient diabetic clinic of Tomas Bata Hospital in Zlin in the Czech Republic. Serum creatinine and cystatin C were measured by newly standardized methods and eGFR was calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, which were established in 2012. CKD is defined as GFR below 1.0 ml/s/1.73m2. Results: The mean eGFRcreatinine (1.443 ± 0.014) ml/s/1.73m2 was lower than eGFRcystatin C (1.512 ± 0.017) ml/s/1.73m 2, (p < 0.002). We found poor accordance to identify CKD. The discrepancy was found in 38 patients. Conclusion: Mean eGFRcystatin C was significantly higher than eGFRcreatinine. eGFR cystatin C gives higher values than eGFRcreatinine mainly at eGFR over 1.5 ml/s/1.73m2. Our results support the use of both eGFRcystatin C and eGFRcreatinine +cystatin C in patients with diabetes mellitus without albuminuria or another marker of kidney damage at GFR stages 2 and 3a according to eGFRcreatinine.
dcterms:title
Estimated glomerular filtration rate in diabetic patients Estimated glomerular filtration rate in diabetic patients
skos:prefLabel
Estimated glomerular filtration rate in diabetic patients Estimated glomerular filtration rate in diabetic patients
skos:notation
RIV/70883521:28610/14:43871580!RIV15-MSM-28610___
n3:aktivita
n8:V
n3:aktivity
V
n3:cisloPeriodika
1
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n9:5683653
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
15024
n3:idVysledku
RIV/70883521:28610/14:43871580
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Glomerular filtration rate; Cystatin C; Creatinine; Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI); Chronic kidney disease
n3:klicoveSlovo
n6:Cystatin%20C n6:Chronic%20Kidney%20Disease%20Epidemiology%20Collaboration%20%28CKD-EPI%29 n6:Glomerular%20filtration%20rate n6:Chronic%20kidney%20disease n6:Creatinine
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3601479E160A]
n3:nazevZdroje
Klinická Biochemie a Metabolismus
n3:obor
n14:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
22
n3:tvurceVysledku
Šálek, Tomáš Ponížil, Petr
s:issn
1210-7921
s:numberOfPages
4
n13:organizacniJednotka
28610