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Statements

Subject Item
n2:RIV%2F70883521%3A28610%2F14%3A43871571%21RIV15-MSM-28610___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/pat.3241/abstract;jsessionid=250322A2EAF391DE2F0900AE63BC3EC1.f03t02
dcterms:description
The work presented here investigates the synthesis of poly(lactic acid)-poly(ethylene oxide) diisocyanate chain-linked copolymer, and its application in the nano-encapsulation of bioactive compounds. Study was conducted on the effect of the type of chain-linking agent, along with molecular weight, thermal properties and hydrophilic/hydrophobic behavior, through the methods of gel permeation chromatography, Fourier transform infrared spectroscopy-attenuated total reflectance, differential scanning calorimetry, light scattering, water uptake experimentation, and water contact angle measurements. Nanoparticle formation was performed via a single solvent evaporation process, and the particles obtained were characterized by dynamic light scattering and scanning electron microscopy. Results show the significantly enhanced molecular weight of the final product after the chain-linking reaction (up to 300,000 g/mol), as well as the non-linear nature of the sample due to broad polydispersity, ranging from 4-13. The final products exhibited glass transition temperatures of between 30 and 44 degrees C, while their crystalline quality was either significantly suppressed or a completely amorphous attribute was observed. Nanoparticles in the range of 300 nm that contained metazachlor were successfully prepared, and their releasing behavior exhibited first order release kinetics. A slower rate of release was observed in samples containing 4,4'-methylenebis(phenyl isocyanate) as a chain-linker. The work presented here investigates the synthesis of poly(lactic acid)-poly(ethylene oxide) diisocyanate chain-linked copolymer, and its application in the nano-encapsulation of bioactive compounds. Study was conducted on the effect of the type of chain-linking agent, along with molecular weight, thermal properties and hydrophilic/hydrophobic behavior, through the methods of gel permeation chromatography, Fourier transform infrared spectroscopy-attenuated total reflectance, differential scanning calorimetry, light scattering, water uptake experimentation, and water contact angle measurements. Nanoparticle formation was performed via a single solvent evaporation process, and the particles obtained were characterized by dynamic light scattering and scanning electron microscopy. Results show the significantly enhanced molecular weight of the final product after the chain-linking reaction (up to 300,000 g/mol), as well as the non-linear nature of the sample due to broad polydispersity, ranging from 4-13. The final products exhibited glass transition temperatures of between 30 and 44 degrees C, while their crystalline quality was either significantly suppressed or a completely amorphous attribute was observed. Nanoparticles in the range of 300 nm that contained metazachlor were successfully prepared, and their releasing behavior exhibited first order release kinetics. A slower rate of release was observed in samples containing 4,4'-methylenebis(phenyl isocyanate) as a chain-linker.
dcterms:title
Novel poly(lactic acid)-poly(ethylene oxide) chain-linked copolymer and its application in nano-encapsulation Novel poly(lactic acid)-poly(ethylene oxide) chain-linked copolymer and its application in nano-encapsulation
skos:prefLabel
Novel poly(lactic acid)-poly(ethylene oxide) chain-linked copolymer and its application in nano-encapsulation Novel poly(lactic acid)-poly(ethylene oxide) chain-linked copolymer and its application in nano-encapsulation
skos:notation
RIV/70883521:28610/14:43871571!RIV15-MSM-28610___
n5:aktivita
n11:S n11:P
n5:aktivity
P(ED2.1.00/03.0111), P(GAP108/10/0200), S
n5:cisloPeriodika
6
n5:dodaniDat
n17:2015
n5:domaciTvurceVysledku
n7:8588716 n7:2967049 n7:3382257 n7:3917436 n7:6339603
n5:druhVysledku
n8:J
n5:duvernostUdaju
n20:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
33107
n5:idVysledku
RIV/70883521:28610/14:43871571
n5:jazykVysledku
n15:eng
n5:klicovaSlova
encapsulation; nanoparticles; diizocyanates; chain-linking; polylactide
n5:klicoveSlovo
n9:chain-linking n9:diizocyanates n9:polylactide n9:nanoparticles n9:encapsulation
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[015B1CC4929D]
n5:nazevZdroje
Polymers for Advanced Technologies
n5:obor
n16:CD
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
5
n5:projekt
n13:ED2.1.00%2F03.0111 n13:GAP108%2F10%2F0200
n5:rokUplatneniVysledku
n17:2014
n5:svazekPeriodika
25
n5:tvurceVysledku
Stloukal, Petr Sedlařík, Vladimír Kucharczyk, Pavel Pavelková, Alena Koutný, Marek
n5:wos
000337680300002
s:issn
1042-7147
s:numberOfPages
10
n12:doi
10.1002/pat.3241
n18:organizacniJednotka
28610