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Statements

Subject Item
n2:RIV%2F70883521%3A28610%2F11%3A43866347%21RIV12-MSM-28610___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The influence of various surfactants and their combinations on the particle diameter and particles size distribution during their preparation from biodegradable poly(lactide acid) by the method of emulsification and solvent evaporation at reduced pressure was investigated. The attention was focused on the possibility to control the size of resultant particles by hydrophilic-lipophilic balance parameter (HLB), which is a characteristic of nonionic surfactants. First, nonionic surfactants were combined to obtain various HLB values of the system and then combinations with the biodegradable surface active polymer Gelatin A were assayed. Gelatin A proved to be a suitable emulsion stabilizer in the process of PLA submicroparticles preparation and it was found that to achieve PLA submicroparticles with the lowest diameter and narrow distribution HLB of the system has to be set up under about 16. For combinations of gelatin A and another nonionic surfactant the reduction of the aggregate HLB value of the system could better be achieved with an addition of a surfactant having HLB closer to the optimum like Tween 20 or Tween 85. The influence of various surfactants and their combinations on the particle diameter and particles size distribution during their preparation from biodegradable poly(lactide acid) by the method of emulsification and solvent evaporation at reduced pressure was investigated. The attention was focused on the possibility to control the size of resultant particles by hydrophilic-lipophilic balance parameter (HLB), which is a characteristic of nonionic surfactants. First, nonionic surfactants were combined to obtain various HLB values of the system and then combinations with the biodegradable surface active polymer Gelatin A were assayed. Gelatin A proved to be a suitable emulsion stabilizer in the process of PLA submicroparticles preparation and it was found that to achieve PLA submicroparticles with the lowest diameter and narrow distribution HLB of the system has to be set up under about 16. For combinations of gelatin A and another nonionic surfactant the reduction of the aggregate HLB value of the system could better be achieved with an addition of a surfactant having HLB closer to the optimum like Tween 20 or Tween 85.
dcterms:title
Optimization of biodegradable polymeric submicroparticles preparation Optimization of biodegradable polymeric submicroparticles preparation
skos:prefLabel
Optimization of biodegradable polymeric submicroparticles preparation Optimization of biodegradable polymeric submicroparticles preparation
skos:notation
RIV/70883521:28610/11:43866347!RIV12-MSM-28610___
n15:predkladatel
n18:orjk%3A28610
n3:aktivita
n4:S n4:P n4:Z
n3:aktivity
P(ED2.1.00/03.0111), P(GAP108/10/0200), S, Z(MSM7088352101)
n3:dodaniDat
n21:2012
n3:domaciTvurceVysledku
n10:3382257 n10:8588716 n10:6339603
n3:druhVysledku
n13:D
n3:duvernostUdaju
n23:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
218736
n3:idVysledku
RIV/70883521:28610/11:43866347
n3:jazykVysledku
n11:eng
n3:klicovaSlova
microparticles, poly(lactide acid), Oil-in-water (O/W) emulsion solvent evaporation method, biodegradable copolymer, nonionic surfactant, gelatin
n3:klicoveSlovo
n8:gelatin n8:Oil-in-water%20%28O%2FW%29%20emulsion%20solvent%20evaporation%20method n8:microparticles n8:poly%28lactide%20acid%29 n8:nonionic%20surfactant n8:biodegradable%20copolymer
n3:kontrolniKodProRIV
[C579C83DDC86]
n3:mistoKonaniAkce
Corfu Island
n3:mistoVydani
Rhodes
n3:nazevZdroje
Recent Researches in Geography, Geology, Energy, Environment and Biomedicine - Proc. of the 4th WSEAS Int. Conf. on EMESEG'11, 2nd Int. Conf. on WORLD-GEO'11, 5th Int. Conf. on EDEB'11
n3:obor
n17:EE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n6:GAP108%2F10%2F0200 n6:ED2.1.00%2F03.0111
n3:rokUplatneniVysledku
n21:2011
n3:tvurceVysledku
Kucharczyk, Pavel Stloukal, Petr Koutný, Marek Sedlařík, Vladimír
n3:typAkce
n19:EUR
n3:zahajeniAkce
2011-07-14+02:00
n3:zamer
n12:MSM7088352101
s:numberOfPages
6
n9:hasPublisher
WSEAS Press (GR)
n14:isbn
978-1-61804-022-0
n16:organizacniJednotka
28610