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Statements

Subject Item
n2:RIV%2F70883521%3A28610%2F11%3A43866050%21RIV12-MSM-28610___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
The low molecular weight biodegradable poly(lactide acid) (PLA) was tested as suitable material for encapsulation of bioactive agent into microparticles by the method of emulsification and solvent evaporation at reduced pressure. The attention was focused on the examination of encapsulation capacity for incorporation of a model herbicide. The initial amount of herbicide was altered and parameters characterizing microparticles like encapsulation efficiency, size and shape were evaluated by different methods. Low molecular PLA proved to be a suitable matrix for easy encapsulation of bioactive compounds by the oil-in-water emulsion solvent evaporation method, furthermore without significant changes in particles size. The relative lowest loss of herbicide along with the highest encapsulation efficiency was achieved for the highest initial concentration of herbicide which is close to the critical concentration under which the particles could still be prepared. The low molecular weight biodegradable poly(lactide acid) (PLA) was tested as suitable material for encapsulation of bioactive agent into microparticles by the method of emulsification and solvent evaporation at reduced pressure. The attention was focused on the examination of encapsulation capacity for incorporation of a model herbicide. The initial amount of herbicide was altered and parameters characterizing microparticles like encapsulation efficiency, size and shape were evaluated by different methods. Low molecular PLA proved to be a suitable matrix for easy encapsulation of bioactive compounds by the oil-in-water emulsion solvent evaporation method, furthermore without significant changes in particles size. The relative lowest loss of herbicide along with the highest encapsulation efficiency was achieved for the highest initial concentration of herbicide which is close to the critical concentration under which the particles could still be prepared.
dcterms:title
Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles
skos:prefLabel
Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles Factors influencing encapsulation efficiency of biologically active compound into PLA submikroparticles
skos:notation
RIV/70883521:28610/11:43866050!RIV12-MSM-28610___
n8:predkladatel
n9:orjk%3A28610
n4:aktivita
n5:S n5:P n5:Z
n4:aktivity
P(ED2.1.00/03.0111), P(GAP108/10/0200), S, Z(MSM7088352101)
n4:dodaniDat
n10:2012
n4:domaciTvurceVysledku
n7:6339603 n7:3382257 n7:8588716
n4:druhVysledku
n21:D
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
199203
n4:idVysledku
RIV/70883521:28610/11:43866050
n4:jazykVysledku
n17:eng
n4:klicovaSlova
microparticles, poly(lactide acid), Oil-in-water (O/W) emulsion solvent evaporation method, encapsulation, HPLC, biodegradable copolymer
n4:klicoveSlovo
n6:Oil-in-water%20%28O%2FW%29%20emulsion%20solvent%20evaporation%20method n6:HPLC n6:microparticles n6:biodegradable%20copolymer n6:encapsulation n6:poly%28lactide%20acid%29
n4:kontrolniKodProRIV
[F8AECE6587B6]
n4:mistoKonaniAkce
Corfu Island
n4:mistoVydani
Rhodes
n4:nazevZdroje
Recent Researches in Geography, Geology, Energy, Environment and Biomedicine - Proc. of the 4th WSEAS Int. Conf. on EMESEG'11, 2nd Int. Conf. on WORLD-GEO'11, 5th Int. Conf. on EDEB'11
n4:obor
n23:EE
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:projekt
n20:ED2.1.00%2F03.0111 n20:GAP108%2F10%2F0200
n4:rokUplatneniVysledku
n10:2011
n4:tvurceVysledku
Kucharczyk, Pavel Stloukal, Petr Koutný, Marek Sedlařík, Vladimír
n4:typAkce
n11:WRD
n4:zahajeniAkce
2011-07-14+02:00
n4:zamer
n16:MSM7088352101
s:numberOfPages
6
n22:hasPublisher
WSEAS Press (GR)
n18:isbn
978-1-61804-022-0
n19:organizacniJednotka
28610