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Statements

Subject Item
n2:RIV%2F68407700%3A21670%2F12%3A00204764%21RIV13-MSM-21670___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Radiotherapy with carbon ion beams is a highly precise method for cancer treatment. This is due to the finite range and the relatively low lateral scattering of the ions. However, on their path through tissue, the carbon ions may undergo nuclear fragmentation, resulting in lighter but energetic projectile fragments. Since the biological effect of the fragments differs from the primary particles, it is important to consider fragmentation in beam models used for therapy planning. Until now, large apparatus have been utilized for ion spectroscopic measurements. Employing a small detector would allow investigations directly within therapy relevant phantoms.We used the Timepix detector, consisting of a 300m thick silicon sensor bump-bonded to a readout chip with 256 x 256 square pixels (55m pitch). The high spatial resolution enables to visualize and distinguish tracks of single particles. The pixel-wise energy calibration allows to directly determine the particle energy loss in the sensitive layer. Charge released in the detector by an ion spreads out during charge collection and is collected by several adjacent pixels forming signal clusters. Experiments were performed at the Heidelberg Ion-Beam Therapy Center, using a carbon ion pencil beam of E=271 MeV/u. To investigate fragments in different material depths, the detector was placed perpendicular to the beam with 12 to 45 cm thick PMMA slabs in front of it. Pattern recognition analysis of the signal showed a clear dependence of cluster parameter distributions on the PMMA depth. This was used to identify the particular particle species in the obtained spectra. In this way, discrimination between primary carbon ions and hydrogen, helium and heavier fragments is possible. The presented novel method enables fragment distinction in mixed particle fields. Its main advantage lies in the flexibility of the set-up. Radiotherapy with carbon ion beams is a highly precise method for cancer treatment. This is due to the finite range and the relatively low lateral scattering of the ions. However, on their path through tissue, the carbon ions may undergo nuclear fragmentation, resulting in lighter but energetic projectile fragments. Since the biological effect of the fragments differs from the primary particles, it is important to consider fragmentation in beam models used for therapy planning. Until now, large apparatus have been utilized for ion spectroscopic measurements. Employing a small detector would allow investigations directly within therapy relevant phantoms.We used the Timepix detector, consisting of a 300m thick silicon sensor bump-bonded to a readout chip with 256 x 256 square pixels (55m pitch). The high spatial resolution enables to visualize and distinguish tracks of single particles. The pixel-wise energy calibration allows to directly determine the particle energy loss in the sensitive layer. Charge released in the detector by an ion spreads out during charge collection and is collected by several adjacent pixels forming signal clusters. Experiments were performed at the Heidelberg Ion-Beam Therapy Center, using a carbon ion pencil beam of E=271 MeV/u. To investigate fragments in different material depths, the detector was placed perpendicular to the beam with 12 to 45 cm thick PMMA slabs in front of it. Pattern recognition analysis of the signal showed a clear dependence of cluster parameter distributions on the PMMA depth. This was used to identify the particular particle species in the obtained spectra. In this way, discrimination between primary carbon ions and hydrogen, helium and heavier fragments is possible. The presented novel method enables fragment distinction in mixed particle fields. Its main advantage lies in the flexibility of the set-up.
dcterms:title
Towards Fragment Distinction in Therapeutic Carbon Ion Beams: A Novel Experimental Approach Using the Timepix Detector Towards Fragment Distinction in Therapeutic Carbon Ion Beams: A Novel Experimental Approach Using the Timepix Detector
skos:prefLabel
Towards Fragment Distinction in Therapeutic Carbon Ion Beams: A Novel Experimental Approach Using the Timepix Detector Towards Fragment Distinction in Therapeutic Carbon Ion Beams: A Novel Experimental Approach Using the Timepix Detector
skos:notation
RIV/68407700:21670/12:00204764!RIV13-MSM-21670___
n11:predkladatel
n12:orjk%3A21670
n3:aktivita
n16:P
n3:aktivity
P(LC06041)
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n17:1338226 Granja, Carlos Humberto n17:9985522
n3:druhVysledku
n20:D
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n22:predkladatel
n3:idSjednocenehoVysledku
174711
n3:idVysledku
RIV/68407700:21670/12:00204764
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Ion beam therapy; radiotherapy; pixel detector
n3:klicoveSlovo
n15:radiotherapy n15:Ion%20beam%20therapy n15:pixel%20detector
n3:kontrolniKodProRIV
[DF28B23451CD]
n3:mistoKonaniAkce
Anaheim
n3:mistoVydani
Piscataway
n3:nazevZdroje
2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)
n3:obor
n13:BG
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n4:LC06041
n3:rokUplatneniVysledku
n7:2012
n3:tvurceVysledku
Gwosch, K. Martisikova, M. Granja, Carlos Humberto Jaekel, O. Jakůbek, Jan Hartmann, B. Pospíšil, Stanislav
n3:typAkce
n21:WRD
n3:zahajeniAkce
2012-10-29+01:00
s:issn
1095-7863
s:numberOfPages
4
n10:hasPublisher
Institute of Electrical and Electronic Engineers
n18:isbn
978-1-4673-2029-0
n6:organizacniJednotka
21670