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Statements

Subject Item
n2:RIV%2F68407700%3A21460%2F13%3A00217378%21RIV15-MSM-21460___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Aims: The non-invasive 13C-methacetin (13C-MBT) breath test has been proposed as a measure of metabolic liver function that improves the diagnostic efficacy of serologic and biochemical tests in assessing hepatic functional capacity and liver disease severity, The goal of this study was to establish the clinical utility of this test in quantifying hepatic metabolic function in patients with liver cirrhosis of varying severity and to compare 13C-MBT measurements with the AST/ALT ratio, APRI score, and other routine liver tests. Methods: Routine liver function tests including serum bilirubin, aspartate aminotransferase activity (AST), alanine aminotransferase (ALT), AST/ALT ratio, the APRI score, the percentage of dose rate (PDR) and cumulative percentage of dose rate (CPDR) of the 13C-MBT were evaluated in 52 cirrhotic patients of alcohol etiology (Child-Pugh A/B/C 10/28/14) and 37 healthy controls. Results: The 13C-MBT differed significantly between healthy controls and cirrhotic patients at all time intervals measured. It also proved the ability to differentiate patients with liver cirrhosis based on severity of hepatic impairment corresponding to the Child-Pugh classification A vs. B vs. C. The ROC curve analysis suggested that the best prediction is provided by time intervals between the 10th - 20th or 10th - 40th minute of PDR. Conclusions: The 13C-MBT offers a reliable means for quantification of hepatic metabolic function over the complete range of functional liver impairment. It is non-invasive, easy to perform and completely safe. Aims: The non-invasive 13C-methacetin (13C-MBT) breath test has been proposed as a measure of metabolic liver function that improves the diagnostic efficacy of serologic and biochemical tests in assessing hepatic functional capacity and liver disease severity, The goal of this study was to establish the clinical utility of this test in quantifying hepatic metabolic function in patients with liver cirrhosis of varying severity and to compare 13C-MBT measurements with the AST/ALT ratio, APRI score, and other routine liver tests. Methods: Routine liver function tests including serum bilirubin, aspartate aminotransferase activity (AST), alanine aminotransferase (ALT), AST/ALT ratio, the APRI score, the percentage of dose rate (PDR) and cumulative percentage of dose rate (CPDR) of the 13C-MBT were evaluated in 52 cirrhotic patients of alcohol etiology (Child-Pugh A/B/C 10/28/14) and 37 healthy controls. Results: The 13C-MBT differed significantly between healthy controls and cirrhotic patients at all time intervals measured. It also proved the ability to differentiate patients with liver cirrhosis based on severity of hepatic impairment corresponding to the Child-Pugh classification A vs. B vs. C. The ROC curve analysis suggested that the best prediction is provided by time intervals between the 10th - 20th or 10th - 40th minute of PDR. Conclusions: The 13C-MBT offers a reliable means for quantification of hepatic metabolic function over the complete range of functional liver impairment. It is non-invasive, easy to perform and completely safe.
dcterms:title
C-13-methacetin breath test in the evaluation of disease severity in patients with liver cirrhosis C-13-methacetin breath test in the evaluation of disease severity in patients with liver cirrhosis
skos:prefLabel
C-13-methacetin breath test in the evaluation of disease severity in patients with liver cirrhosis C-13-methacetin breath test in the evaluation of disease severity in patients with liver cirrhosis
skos:notation
RIV/68407700:21460/13:00217378!RIV15-MSM-21460___
n4:aktivita
n10:V n10:O n10:P
n4:aktivity
O, P(ED0030/01/01), V
n4:cisloPeriodika
4
n4:dodaniDat
n14:2015
n4:domaciTvurceVysledku
n11:6151388 n11:6750583
n4:druhVysledku
n13:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
67808
n4:idVysledku
RIV/68407700:21460/13:00217378
n4:jazykVysledku
n17:eng
n4:klicovaSlova
13C-methacetin breath test; cirrhosis; Child-Pugh classification; non-dispersive infrared spectroscopy; aldehyde dehydrogenase; alcohol dehydrogenase; cytochrome P450; catalase
n4:klicoveSlovo
n5:alcohol%20dehydrogenase n5:cirrhosis n5:aldehyde%20dehydrogenase n5:Child-Pugh%20classification n5:cytochrome%20P450 n5:13C-methacetin%20breath%20test n5:catalase n5:non-dispersive%20infrared%20spectroscopy
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[40714010FA24]
n4:nazevZdroje
Biomedical Papers
n4:obor
n12:FQ
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
6
n4:projekt
n7:ED0030%2F01%2F01
n4:rokUplatneniVysledku
n14:2013
n4:svazekPeriodika
157
n4:tvurceVysledku
Krátká, K. Hendrichová, M. Vránová, Jana Horák, J. Kolářová, H. Rosina, Jozef
n4:wos
000329091500021
s:issn
1213-8118
s:numberOfPages
9
n18:organizacniJednotka
21460