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Statements

Subject Item
n2:RIV%2F68407700%3A21460%2F13%3A00209583%21RIV14-MSM-21460___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://www.biomedcentral.com/content/pdf/1471-2393-13-217.pdf
dcterms:description
Background Hypothyroidism and/or autoimmune thyroid disorders (AITD) may contribute to spontaneous abortions (SpA). Cost-effectiveness analyses of thyroid screening in women after SpA are lacking. Our aim was to evaluate the cost-effectiveness of screening for AITD and/or hypothyroidism and their treatment in women after SpA with regard to their reproductive health. Methods We performed a cross-sectional non-randomized study with follow-up in 2008--2011 in the settings of Departments of Endocrinology and Obstetrics/Gynecology of a university hospital. We enrolled 258 women after SpA before the 12th gestational week and followed them for a median of 3 years. At enrollment, serum concentrations of thyroid stimulatory hormone (TSH), antibodies to thyroid peroxidase (TPOAb) and free thyroxine (FT4) were measured and thyroid ultrasound performed. Women with overt hypothyroidism were treated with levothyroxine (n = 45; 61.6%) and women with subclinical hypothyroidism or euthyroid AITD were treated (n = 28; 38.4%) or left untreated (n = 38; 14.7%). Euthyroid women without signs of AITD served as controls (n = 147; 57.0%). Results Of the 38 untreated women with AITD and/or subclinical hypothyroidism, 8 (21.1%) reported secondary infertility as compared to 16/147 (10.9%) controls and 3/73 (4.1%) treated women (p = 0.021). Treatment was associated with an increased rate of successfully completed subsequent pregnancies (increment of 6 newborns/100 women) and a savings of [euro sign]19,539/100 women. Total costs per successfully completed pregnancy were [euro sign]1,189 in controls, [euro sign]1,564 in the treated, and [euro sign]2,488 in the untreated women. Conclusions Screening for thyroid disorders in women after SpA and treatment with levothyroxine is cost-saving and it improves the subsequent pregnancy rate. Background Hypothyroidism and/or autoimmune thyroid disorders (AITD) may contribute to spontaneous abortions (SpA). Cost-effectiveness analyses of thyroid screening in women after SpA are lacking. Our aim was to evaluate the cost-effectiveness of screening for AITD and/or hypothyroidism and their treatment in women after SpA with regard to their reproductive health. Methods We performed a cross-sectional non-randomized study with follow-up in 2008--2011 in the settings of Departments of Endocrinology and Obstetrics/Gynecology of a university hospital. We enrolled 258 women after SpA before the 12th gestational week and followed them for a median of 3 years. At enrollment, serum concentrations of thyroid stimulatory hormone (TSH), antibodies to thyroid peroxidase (TPOAb) and free thyroxine (FT4) were measured and thyroid ultrasound performed. Women with overt hypothyroidism were treated with levothyroxine (n = 45; 61.6%) and women with subclinical hypothyroidism or euthyroid AITD were treated (n = 28; 38.4%) or left untreated (n = 38; 14.7%). Euthyroid women without signs of AITD served as controls (n = 147; 57.0%). Results Of the 38 untreated women with AITD and/or subclinical hypothyroidism, 8 (21.1%) reported secondary infertility as compared to 16/147 (10.9%) controls and 3/73 (4.1%) treated women (p = 0.021). Treatment was associated with an increased rate of successfully completed subsequent pregnancies (increment of 6 newborns/100 women) and a savings of [euro sign]19,539/100 women. Total costs per successfully completed pregnancy were [euro sign]1,189 in controls, [euro sign]1,564 in the treated, and [euro sign]2,488 in the untreated women. Conclusions Screening for thyroid disorders in women after SpA and treatment with levothyroxine is cost-saving and it improves the subsequent pregnancy rate.
dcterms:title
Screening for autoimmune thyroid disorders after spontaneous abortion is cost-saving and it improves the subsequent pregnancy rate Screening for autoimmune thyroid disorders after spontaneous abortion is cost-saving and it improves the subsequent pregnancy rate
skos:prefLabel
Screening for autoimmune thyroid disorders after spontaneous abortion is cost-saving and it improves the subsequent pregnancy rate Screening for autoimmune thyroid disorders after spontaneous abortion is cost-saving and it improves the subsequent pregnancy rate
skos:notation
RIV/68407700:21460/13:00209583!RIV14-MSM-21460___
n18:predkladatel
n19:orjk%3A21460
n4:aktivita
n6:I n6:S
n4:aktivity
I, S
n4:cisloPeriodika
listopad
n4:dodaniDat
n17:2014
n4:domaciTvurceVysledku
n9:7964218
n4:druhVysledku
n11:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
104142
n4:idVysledku
RIV/68407700:21460/13:00209583
n4:jazykVysledku
n10:eng
n4:klicovaSlova
autoimmune thyroid disorders; spontaneous abortion; CEA
n4:klicoveSlovo
n5:autoimmune%20thyroid%20disorders n5:spontaneous%20abortion n5:CEA
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[91124A742A3E]
n4:nazevZdroje
BMC Pregnancy and Childbirth
n4:obor
n16:FB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
8
n4:rokUplatneniVysledku
n17:2013
n4:svazekPeriodika
13
n4:tvurceVysledku
Schöndorfová, D. Jiskra, J. Telička, Z. Potluková, E. Bartáková, Jana Rogalewicz, Vladimír Fait, T. Krátký, J.
n4:wos
000329248100002
s:issn
1471-2393
s:numberOfPages
9
n15:doi
10.1186/1471-2393-13-217
n14:organizacniJednotka
21460