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Statements

Subject Item
n2:RIV%2F68407700%3A21460%2F12%3A00201975%21RIV13-MSM-21460___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quantal size variation causing the spike time jitter to vary from 0.03 ms to 0.6 ms. Least influential was the voltage-gated channel noise generating spike jitter from 0.02 ms to 0.15 ms. Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quantal size variation causing the spike time jitter to vary from 0.03 ms to 0.6 ms. Least influential was the voltage-gated channel noise generating spike jitter from 0.02 ms to 0.15 ms.
dcterms:title
The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
skos:prefLabel
The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
skos:notation
RIV/68407700:21460/12:00201975!RIV13-MSM-21460___
n17:predkladatel
n18:orjk%3A21460
n3:aktivita
n14:Z n14:I n14:P
n3:aktivity
I, P(FR-TI3/869), P(GP305/05/P198), Z(MSM0021620806)
n3:cisloPeriodika
Leden
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n15:1152548
n3:druhVysledku
n7:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
133168
n3:idVysledku
RIV/68407700:21460/12:00201975
n3:jazykVysledku
n21:eng
n3:klicovaSlova
NEOCORTICAL PYRAMIDAL NEURONS; RAT HIPPOCAMPAL-NEURONS; RETINAL GANGLION-CELLS; TIMING PRECISION; TEMPORAL PRECISION; SYNAPTIC-TRANSMISSION; POTASSIUM CHANNELS; CORTICAL-NEURONS; IN-VITRO; AREA CA1
n3:klicoveSlovo
n10:SYNAPTIC-TRANSMISSION n10:AREA%20CA1 n10:TIMING%20PRECISION n10:NEOCORTICAL%20PYRAMIDAL%20NEURONS n10:TEMPORAL%20PRECISION n10:RETINAL%20GANGLION-CELLS n10:IN-VITRO n10:RAT%20HIPPOCAMPAL-NEURONS n10:CORTICAL-NEURONS n10:POTASSIUM%20CHANNELS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[69ACB29A69ED]
n3:nazevZdroje
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
n3:obor
n13:JD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n16:FR-TI3%2F869 n16:GP305%2F05%2FP198
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
2012
n3:tvurceVysledku
Štroffek, J. Wünsch, Z. Maršálek, Petr Kuriščák, E.
n3:wos
000307564100001
n3:zamer
n20:MSM0021620806
s:issn
1748-670X
s:numberOfPages
16
n9:doi
10.1155/2012/595398
n5:organizacniJednotka
21460