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Statements

Subject Item
n2:RIV%2F68407700%3A21340%2F12%3A00199955%21RIV13-MSM-21340___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Metastatic spread was observed in both groups and reached 80 A in PAR2-/- and 50 % in control animals. While in control mice only lung metastases were observed, local tumour recurrence, renal and lung metastases were observed in PAR2-/- mice. The absence of functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo, probably associated with tumour cell migration, invasiveness and metastasis formation. Metastatic spread was observed in both groups and reached 80 A in PAR2-/- and 50 % in control animals. While in control mice only lung metastases were observed, local tumour recurrence, renal and lung metastases were observed in PAR2-/- mice. The absence of functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo, probably associated with tumour cell migration, invasiveness and metastasis formation.
dcterms:title
PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals
skos:prefLabel
PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals
skos:notation
RIV/68407700:21340/12:00199955!RIV13-MSM-21340___
n10:predkladatel
n18:orjk%3A21340
n3:aktivita
n17:S n17:P n17:I
n3:aktivity
I, P(GP309/09/P204), P(NS10423), S
n3:cisloPeriodika
2
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n8:2685337
n3:druhVysledku
n19:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
157904
n3:idVysledku
RIV/68407700:21340/12:00199955
n3:jazykVysledku
n6:eng
n3:klicovaSlova
PAR-2; trypsin; melanoma; metastasis; knock-out
n3:klicoveSlovo
n13:PAR-2 n13:metastasis n13:melanoma n13:trypsin n13:knock-out
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[7EA31115B899]
n3:nazevZdroje
Folia Biologica
n3:obor
n15:JD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:projekt
n9:NS10423 n9:GP309%2F09%2FP204
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
58
n3:tvurceVysledku
Zadinova, M. Poucková, P. Kukal, Jaromír Olejar, T. Matej, R.
n3:wos
000303140600006
s:issn
0015-5500
s:numberOfPages
6
n7:organizacniJednotka
21340