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Statements

Subject Item
n2:RIV%2F68407700%3A21260%2F12%3A00198317%21RIV13-GA0-21260___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The fluorescence in-situ hybridization (FISH) belongs to the most common cytogenetic methods and is widely applied in routine clinical genetic diagnostics. We are paying attention to FISH analysis of chromosomal aneuploidies - the deviations from chromosomal number. Such analysis is based on evaluation of up to several hundreds of microscopic images. Computer support for this process includes using methods of image processing and data mining. In this paper, we focus on the image processing part in more detail: first, the properties of FISH images are reviewed, then, the processing flow is outlined. Our aim is to find the interphase and metaphase nuclei and the hybridization signals contained in the image. A simple method using the raw and central moments of detected objects as measures to distinguish between the two types of nuclei is proposed. The fluorescence in-situ hybridization (FISH) belongs to the most common cytogenetic methods and is widely applied in routine clinical genetic diagnostics. We are paying attention to FISH analysis of chromosomal aneuploidies - the deviations from chromosomal number. Such analysis is based on evaluation of up to several hundreds of microscopic images. Computer support for this process includes using methods of image processing and data mining. In this paper, we focus on the image processing part in more detail: first, the properties of FISH images are reviewed, then, the processing flow is outlined. Our aim is to find the interphase and metaphase nuclei and the hybridization signals contained in the image. A simple method using the raw and central moments of detected objects as measures to distinguish between the two types of nuclei is proposed.
dcterms:title
Automated Detection of Interphase and Metaphase Nuclei in the FISH Images Automated Detection of Interphase and Metaphase Nuclei in the FISH Images
skos:prefLabel
Automated Detection of Interphase and Metaphase Nuclei in the FISH Images Automated Detection of Interphase and Metaphase Nuclei in the FISH Images
skos:notation
RIV/68407700:21260/12:00198317!RIV13-GA0-21260___
n15:predkladatel
n16:orjk%3A21260
n3:aktivita
n20:Z n20:P
n3:aktivity
P(GAP102/11/1795), P(TA01010931), Z(AV0Z10750506)
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n13:5081068
n3:druhVysledku
n4:D
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
124176
n3:idVysledku
RIV/68407700:21260/12:00198317
n3:jazykVysledku
n22:eng
n3:klicovaSlova
FISH; cytogenetic; image processing
n3:klicoveSlovo
n5:cytogenetic n5:FISH n5:image%20processing
n3:kontrolniKodProRIV
[812EB69A9CCF]
n3:mistoKonaniAkce
Vilamoura
n3:mistoVydani
Porto
n3:nazevZdroje
BIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
n3:obor
n14:IN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:projekt
n10:TA01010931 n10:GAP102%2F11%2F1795
n3:rokUplatneniVysledku
n7:2012
n3:tvurceVysledku
Schier, J. Kovář, Bohumil Kočárek, E.
n3:typAkce
n19:WRD
n3:zahajeniAkce
2012-02-01+01:00
n3:zamer
n12:AV0Z10750506
s:numberOfPages
4
n23:hasPublisher
SciTePress - Science and Technology Publications
n18:isbn
978-989-8425-90-4
n21:organizacniJednotka
21260