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Statements

Subject Item
n2:RIV%2F68407700%3A21230%2F14%3A00223616%21RIV15-MSM-21230___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://csskn2014.upol.cz/site2014/wp-content/uploads/2014/05/abstracts_tematicke_sekce_sjezdu.pdf
dcterms:description
Rationale: The irritative zone is an area of the brain generating interictal epileptiform discharges (IEDs) that is used together with other results when planning epilepsy surgery. This zone possesses relatively low diagnostic value due to lack of a specific marker that would identify IEDs generated within the epileptogenic tissue. To increase diagnostic yield of irritative zone, we examined its functional organization. Methods: Intracranial EEG recordings from 14 patients with refractory neocortical epilepsy were analysed using an algorithm that separates IEDs according to their spatial distribution into clusters. Analysis of cluster properties enabled to determine: 1) activity - percentage contribution to all IEDs in the given recording; 2) origins - the contacts where cluster initiates and 3) active region - the area of the most common propagation. Results: On average 16,868±16,813 IEDs per patient were analysed. The results demonstrated that in all patients the irritative zone was composed of multiple clusters with an average number of 12.5±4.7 clusters per patient. The strongest cluster generated 43.5±18.9% of all IEDs Average size of active region was 4.5±4.5 contacts and contained 2.2±1.7 origins. Evaluation of the cluster resection with the outcome suggested that the topology of the irritative zone may determine the success of the resection. Conclusion: This study demonstrates the complex organization and modular nature of the neocortical irritative zone in epilepsy patients. It can be stratified into functional components, each with distinct pathophysiological and clinical significance. The ability to identify the key components of this network and its topology has potential to improve the results of epilepsy surgery. Rationale: The irritative zone is an area of the brain generating interictal epileptiform discharges (IEDs) that is used together with other results when planning epilepsy surgery. This zone possesses relatively low diagnostic value due to lack of a specific marker that would identify IEDs generated within the epileptogenic tissue. To increase diagnostic yield of irritative zone, we examined its functional organization. Methods: Intracranial EEG recordings from 14 patients with refractory neocortical epilepsy were analysed using an algorithm that separates IEDs according to their spatial distribution into clusters. Analysis of cluster properties enabled to determine: 1) activity - percentage contribution to all IEDs in the given recording; 2) origins - the contacts where cluster initiates and 3) active region - the area of the most common propagation. Results: On average 16,868±16,813 IEDs per patient were analysed. The results demonstrated that in all patients the irritative zone was composed of multiple clusters with an average number of 12.5±4.7 clusters per patient. The strongest cluster generated 43.5±18.9% of all IEDs Average size of active region was 4.5±4.5 contacts and contained 2.2±1.7 origins. Evaluation of the cluster resection with the outcome suggested that the topology of the irritative zone may determine the success of the resection. Conclusion: This study demonstrates the complex organization and modular nature of the neocortical irritative zone in epilepsy patients. It can be stratified into functional components, each with distinct pathophysiological and clinical significance. The ability to identify the key components of this network and its topology has potential to improve the results of epilepsy surgery.
dcterms:title
FUNCTIONAL ORGANIZATION OF THE IRRITATIVE ZONE IN NEOCORTICAL EPILEPSY FUNCTIONAL ORGANIZATION OF THE IRRITATIVE ZONE IN NEOCORTICAL EPILEPSY
skos:prefLabel
FUNCTIONAL ORGANIZATION OF THE IRRITATIVE ZONE IN NEOCORTICAL EPILEPSY FUNCTIONAL ORGANIZATION OF THE IRRITATIVE ZONE IN NEOCORTICAL EPILEPSY
skos:notation
RIV/68407700:21230/14:00223616!RIV15-MSM-21230___
n3:aktivita
n17:S n17:P
n3:aktivity
P(GA14-02634S), S
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n6:2659069 n6:8418500 n6:6532683
n3:druhVysledku
n18:O
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
17662
n3:idVysledku
RIV/68407700:21230/14:00223616
n3:jazykVysledku
n5:eng
n3:klicovaSlova
quantitative EEG; assesment; surgeryirritative zone; neocortical epilepsy
n3:klicoveSlovo
n8:surgeryirritative%20zone n8:neocortical%20epilepsy n8:assesment n8:quantitative%20EEG
n3:kontrolniKodProRIV
[CE6F0D8D8D42]
n3:obor
n12:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
9
n3:projekt
n10:GA14-02634S
n3:rokUplatneniVysledku
n7:2014
n3:tvurceVysledku
Komárek, V. Tomášek, M. Janča, Radek Kršek, P. Jiruška, P. Jefferys, J.G.R. Marusič, P. Ježdík, Petr Čmejla, Roman
n13:organizacniJednotka
21230