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Statements

Subject Item
n2:RIV%2F68407700%3A21230%2F14%3A00211541%21RIV15-MSM-21230___
rdf:type
skos:Concept n6:Vysledek
rdfs:seeAlso
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0086501
dcterms:description
The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computational results predict the existence of a rapidly changing electric field which is generated by either driven or endogenous vibrations of the mitotic spindle. For certain values of parameters, the intensity of the electric field and its gradient reach values which may exert a not-inconsiderable force on chromosomes which are aligned in the spindle midzone. Our model may describe possible mechanisms of the effects of ultra-short electrical and mechanical pulses on dividing cells---a strategy used in novel methods for cancer treatment. The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computational results predict the existence of a rapidly changing electric field which is generated by either driven or endogenous vibrations of the mitotic spindle. For certain values of parameters, the intensity of the electric field and its gradient reach values which may exert a not-inconsiderable force on chromosomes which are aligned in the spindle midzone. Our model may describe possible mechanisms of the effects of ultra-short electrical and mechanical pulses on dividing cells---a strategy used in novel methods for cancer treatment.
dcterms:title
Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model
skos:prefLabel
Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model
skos:notation
RIV/68407700:21230/14:00211541!RIV15-MSM-21230___
n4:aktivita
n15:I n15:S n15:P
n4:aktivity
I, P(GAP102/11/0649), S
n4:cisloPeriodika
1
n4:dodaniDat
n7:2015
n4:domaciTvurceVysledku
n12:7844654
n4:druhVysledku
n13:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
14087
n4:idVysledku
RIV/68407700:21230/14:00211541
n4:jazykVysledku
n18:eng
n4:klicovaSlova
microtubule; mitotic spindle; vibrations
n4:klicoveSlovo
n8:vibrations n8:microtubule n8:mitotic%20spindle
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[F8AACB3D2414]
n4:nazevZdroje
PLoS ONE
n4:obor
n5:BO
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:projekt
n16:GAP102%2F11%2F0649
n4:rokUplatneniVysledku
n7:2014
n4:svazekPeriodika
9
n4:tvurceVysledku
Kučera, O. Cifra, M. Havelka, Daniel Deriu, M.
n4:wos
000330617100018
s:issn
1932-6203
s:numberOfPages
13
n14:doi
10.1371/journal.pone.0086501
n10:organizacniJednotka
21230