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Statements

Subject Item
n2:RIV%2F68407700%3A21220%2F12%3A00193513%21RIV13-MSM-21220___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://users.fs.cvut.cz/~hornyluk/files/How-aging-is-reflected-by-longitudinal-pretension-in-abdominal-aorta-PhD-Horny.pdf
dcterms:description
Studies on the influence of ageing on the longitudinal mechanical response of elastic arteries are rare, though longitudinal behaviour may have a significant effect on pressure pulse wave transmission. Longitudinal prestrain in physiological conditions ensures almost constant length of the artery during the cardiac cycle. This may not, however, be true in aged arteries. Our study was designed to elucidate how ageing is reflected in the longitudinal prestress, prestretch and pretension force. The study involved ten human samples (six female, four male) of the abdominal aorta with longitudinal prestretch determined in autopsy (age 47/12; prestretch 1.13/0.1; mean/SD). Cylindrical samples underwent a longitudinal elongation test in order to estimate the force necessary to attain the in situ length and to determine the corresponding axial stress (prestress). The elastic modulus was estimated employing a limiting chain extensibility model to describe the stress-strain relationship. It was found that pretension force, longitudinal prestress and prestretch are negatively correlated with age. The axial prestress decreases with age within one order of magnitude (from tens of kPa to units of kPa). The decreased longitudinal force necessary to obtain the in situ length suggested that the decrease in the prestress occurs not only due to the age-related increase in the cross-section area. Since elastin is the main constituent responsible bearing the prestretch, this suggests that the observed decrease in the longitudinal prestress and prestretch reflects ageing-induced damage to the elastin. Finally, constitutive modelling showed that limiting chain extensibility is a concept that is suitable for describing the ageing effect. Studies on the influence of ageing on the longitudinal mechanical response of elastic arteries are rare, though longitudinal behaviour may have a significant effect on pressure pulse wave transmission. Longitudinal prestrain in physiological conditions ensures almost constant length of the artery during the cardiac cycle. This may not, however, be true in aged arteries. Our study was designed to elucidate how ageing is reflected in the longitudinal prestress, prestretch and pretension force. The study involved ten human samples (six female, four male) of the abdominal aorta with longitudinal prestretch determined in autopsy (age 47/12; prestretch 1.13/0.1; mean/SD). Cylindrical samples underwent a longitudinal elongation test in order to estimate the force necessary to attain the in situ length and to determine the corresponding axial stress (prestress). The elastic modulus was estimated employing a limiting chain extensibility model to describe the stress-strain relationship. It was found that pretension force, longitudinal prestress and prestretch are negatively correlated with age. The axial prestress decreases with age within one order of magnitude (from tens of kPa to units of kPa). The decreased longitudinal force necessary to obtain the in situ length suggested that the decrease in the prestress occurs not only due to the age-related increase in the cross-section area. Since elastin is the main constituent responsible bearing the prestretch, this suggests that the observed decrease in the longitudinal prestress and prestretch reflects ageing-induced damage to the elastin. Finally, constitutive modelling showed that limiting chain extensibility is a concept that is suitable for describing the ageing effect.
dcterms:title
How Ageing is Reflected by Longitudinal Pretension in Abdominal Aorta How Ageing is Reflected by Longitudinal Pretension in Abdominal Aorta
skos:prefLabel
How Ageing is Reflected by Longitudinal Pretension in Abdominal Aorta How Ageing is Reflected by Longitudinal Pretension in Abdominal Aorta
skos:notation
RIV/68407700:21220/12:00193513!RIV13-MSM-21220___
n14:predkladatel
n16:orjk%3A21220
n3:aktivita
n9:Z n9:I n9:S n9:P
n3:aktivity
I, P(GA106/08/0557), P(TA01010185), S, Z(MSM6840770012)
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n10:2978458
n3:druhVysledku
n15:O
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
139663
n3:idVysledku
RIV/68407700:21220/12:00193513
n3:jazykVysledku
n20:eng
n3:klicovaSlova
ageing; aorta; arteriosclerosis; constitutive modelling; elastin; prestress; prestretch
n3:klicoveSlovo
n5:prestretch n5:aorta n5:elastin n5:arteriosclerosis n5:prestress n5:ageing n5:constitutive%20modelling
n3:kontrolniKodProRIV
[6083E2E1492F]
n3:obor
n17:JJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n13:GA106%2F08%2F0557 n13:TA01010185
n3:rokUplatneniVysledku
n8:2012
n3:tvurceVysledku
Horný, Lukáš
n3:zamer
n19:MSM6840770012
n18:organizacniJednotka
21220