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Statements

Subject Item
n2:RIV%2F68378271%3A_____%2F11%3A00367265%21RIV12-AV0-68378271
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment. Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment.
dcterms:title
Nanomechanics of magnetically driven cellular endocytosis Nanomechanics of magnetically driven cellular endocytosis
skos:prefLabel
Nanomechanics of magnetically driven cellular endocytosis Nanomechanics of magnetically driven cellular endocytosis
skos:notation
RIV/68378271:_____/11:00367265!RIV12-AV0-68378271
n15:predkladatel
n16:ico%3A68378271
n3:aktivita
n13:P n13:Z
n3:aktivity
P(1M06002), P(KAN301370701), Z(AV0Z10100522)
n3:cisloPeriodika
18
n3:dodaniDat
n18:2012
n3:domaciTvurceVysledku
Dejneka, Alexandr n9:6219144 n9:5193222
n3:druhVysledku
n10:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
214788
n3:idVysledku
RIV/68378271:_____/11:00367265
n3:jazykVysledku
n8:eng
n3:klicovaSlova
magnetically controled endocytosis; cell membranes; iron oxide nanoparticles
n3:klicoveSlovo
n7:magnetically%20controled%20endocytosis n7:cell%20membranes n7:iron%20oxide%20nanoparticles
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C44B0371A838]
n3:nazevZdroje
Applied Physics Letters
n3:obor
n20:BM
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n5:KAN301370701 n5:1M06002
n3:rokUplatneniVysledku
n18:2011
n3:svazekPeriodika
99
n3:tvurceVysledku
Dejneka, Alexandr Jastrabík, Lubomír Polyakova, T. Zablotskyy, Vitaliy A. Simmet, T. Lunov, O. Syrovets, T.
n3:wos
000296659400100
n3:zamer
n14:AV0Z10100522
s:issn
0003-6951
s:numberOfPages
3
n11:doi
10.1063/1.3656020