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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F14%3A00442560%21RIV15-AV0-68378050
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Dietary phospholipids (PLs) and their derivatives have proved active in suppression of various health problems and conditions including cancer. In this work we compared the effect of dietary phospholipids from hen egg yolk enriched with N-acyl ether-phosphatidyl ethanolamine (NAEPE) termed bioactive phospholipids (BAP+ preparation) with PLs lacking NAEPE (BAP preparation) on the growth of transformed cells in vitro and on the promotion and progression of experimental tumours in vivo. For the in vivo experiments we used the chicken model in which liver, lung, and kidney tumours arose via natural selection from single cells initiated by experimentally introduced somatic mutations caused by insertional mutagenesis. Mutagenized animals were fed BAP+ or BAP diet in various regimens. We observed that BAP+ at low concentrations killed cells of various tumour cell lines in culture but did not compromise viability of non-transformed cells. Oral administration of the BAP+ preparation efficiently reduced progression of all tumour types. However, it did not significantly reduce the number of already initiated tumours and their growth when BAP+ was discontinued. Our data suggest that NAEPE combined with hen egg PLs significantly interferes with tumour progression, possibly through the inhibition of tumour cell viability. Dietary phospholipids (PLs) and their derivatives have proved active in suppression of various health problems and conditions including cancer. In this work we compared the effect of dietary phospholipids from hen egg yolk enriched with N-acyl ether-phosphatidyl ethanolamine (NAEPE) termed bioactive phospholipids (BAP+ preparation) with PLs lacking NAEPE (BAP preparation) on the growth of transformed cells in vitro and on the promotion and progression of experimental tumours in vivo. For the in vivo experiments we used the chicken model in which liver, lung, and kidney tumours arose via natural selection from single cells initiated by experimentally introduced somatic mutations caused by insertional mutagenesis. Mutagenized animals were fed BAP+ or BAP diet in various regimens. We observed that BAP+ at low concentrations killed cells of various tumour cell lines in culture but did not compromise viability of non-transformed cells. Oral administration of the BAP+ preparation efficiently reduced progression of all tumour types. However, it did not significantly reduce the number of already initiated tumours and their growth when BAP+ was discontinued. Our data suggest that NAEPE combined with hen egg PLs significantly interferes with tumour progression, possibly through the inhibition of tumour cell viability.
dcterms:title
Egg Yolk Phospholipids Enriched with 1-O-Octadecyl-2-Oleoyl-sn-Glycero-3-Phospho-(N-Palmitoyl) Ethanolamine Inhibit Development of Experimentally Induced Tumours Egg Yolk Phospholipids Enriched with 1-O-Octadecyl-2-Oleoyl-sn-Glycero-3-Phospho-(N-Palmitoyl) Ethanolamine Inhibit Development of Experimentally Induced Tumours
skos:prefLabel
Egg Yolk Phospholipids Enriched with 1-O-Octadecyl-2-Oleoyl-sn-Glycero-3-Phospho-(N-Palmitoyl) Ethanolamine Inhibit Development of Experimentally Induced Tumours Egg Yolk Phospholipids Enriched with 1-O-Octadecyl-2-Oleoyl-sn-Glycero-3-Phospho-(N-Palmitoyl) Ethanolamine Inhibit Development of Experimentally Induced Tumours
skos:notation
RIV/68378050:_____/14:00442560!RIV15-AV0-68378050
n3:aktivita
n8:I
n3:aktivity
I
n3:cisloPeriodika
5
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n4:2739623 n4:2631334 n4:8465800
n3:druhVysledku
n5:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
13884
n3:idVysledku
RIV/68378050:_____/14:00442560
n3:jazykVysledku
n13:eng
n3:klicovaSlova
hen egg phospholipids; phospholipid derivative NAEPE; inhibition of tumour cells; inhibition of liver; lung; kidney tumours; chicken model
n3:klicoveSlovo
n7:chicken%20model n7:lung n7:phospholipid%20derivative%20NAEPE n7:inhibition%20of%20liver n7:inhibition%20of%20tumour%20cells n7:hen%20egg%20phospholipids n7:kidney%20tumours
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[352248151633]
n3:nazevZdroje
Folia Biologica
n3:obor
n14:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
60
n3:tvurceVysledku
Karafiát, Vít Veselý, Pavel Dvořák, Michal
n3:wos
000346234100003
s:issn
0015-5500
s:numberOfPages
8