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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F14%3A00436138%21RIV15-AV0-68378050
rdf:type
skos:Concept n17:Vysledek
dcterms:description
ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and prophase, and both osmotic stress and mechanical stretching relocalize ATR to nuclear membranes throughout the cell cycle. The ATR-mediated mechanical response occurs within the range of physiological forces, is reversible, and is independent of DNA damage signaling. ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. We propose that mechanical forces derived from chromosome dynamics and torsional stress on nuclear membranes activate ATR to modulate nuclear envelope plasticity and chromatin association to the nuclear envelope, thus enabling cells to cope with the mechanical strain imposed by these molecular processes. ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and prophase, and both osmotic stress and mechanical stretching relocalize ATR to nuclear membranes throughout the cell cycle. The ATR-mediated mechanical response occurs within the range of physiological forces, is reversible, and is independent of DNA damage signaling. ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. We propose that mechanical forces derived from chromosome dynamics and torsional stress on nuclear membranes activate ATR to modulate nuclear envelope plasticity and chromatin association to the nuclear envelope, thus enabling cells to cope with the mechanical strain imposed by these molecular processes.
dcterms:title
ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress
skos:prefLabel
ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress
skos:notation
RIV/68378050:_____/14:00436138!RIV15-AV0-68378050
n3:aktivita
n9:I n9:P
n3:aktivity
I, P(ED0030/01/01)
n3:cisloPeriodika
3
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n14:6201822 n14:3665453
n3:druhVysledku
n8:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
4462
n3:idVysledku
RIV/68378050:_____/14:00436138
n3:jazykVysledku
n18:eng
n3:klicovaSlova
ATR; Mechanical Stress; cell cycle
n3:klicoveSlovo
n7:Mechanical%20Stress n7:ATR n7:cell%20cycle
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3A7607395267]
n3:nazevZdroje
Cell
n3:obor
n4:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
12
n3:projekt
n12:ED0030%2F01%2F01
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
158
n3:tvurceVysledku
Mistrik, M. Bartek, Jiří Beznoussenko, G. V. Shivashankar, G. V. Košař, Martin Garrè, M. Mironov, A. A. Parazolli, D. Kumar, A. Foiani, M. Scita, G. Mazzanti, M.
n3:wos
000340944300015
s:issn
0092-8674
s:numberOfPages
14
n10:doi
10.1016/j.cell.2014.05.046