This HTML5 document contains 61 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n16http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F68378050%3A_____%2F13%3A00423385%21RIV14-GA0-68378050/
n15http://linked.opendata.cz/resource/domain/vavai/projekt/
n12http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n19http://linked.opendata.cz/resource/domain/vavai/subjekt/
n6http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n18http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n4http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F13%3A00423385%21RIV14-GA0-68378050
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Leishmaniasis, a disease caused by Leishmania ssp. is among the most neglected infectious diseases. In humans, L. tropica causes cutaneous form of leishmaniasis, but can damage internal organs too. The reasons for this variability are not known, and its genetic basis was never investigated. Therefore, analysis of genes affecting host's responses to this infection can elucidate the characteristics of individual host-parasite interactions. Recombinant congenic strain CcS-16 carries 12.5% genes from the mouse strain STS/A on genetic background of the strain BALB/c, and it is more susceptible than BALB/c. In F2 hybrids between BALB/c and CcS-16 we detected and mapped eight gene-loci, Ltr1-8 (Leishmania tropica response 1-8) that control various manifestations of disease: skin lesions, splenomegaly, hepatomegaly, parasite numbers in spleen, liver, and inguinal lymph nodes, and serum level of CCL3, CCL5, and CCL7 after L. tropica infection. These loci are functionally heterogeneous - each influences a different set of responses to the pathogen. Five loci co-localize with the previously described loci that control susceptibility to L. major, three are species-specific. Ltr2 co-localizes not only with Lmr14 (Leishmania major response 14), but also with Ir2 influencing susceptibility to L. donovani and might therefore carry a common gene controlling susceptibility to leishmaniasis. Leishmaniasis, a disease caused by Leishmania ssp. is among the most neglected infectious diseases. In humans, L. tropica causes cutaneous form of leishmaniasis, but can damage internal organs too. The reasons for this variability are not known, and its genetic basis was never investigated. Therefore, analysis of genes affecting host's responses to this infection can elucidate the characteristics of individual host-parasite interactions. Recombinant congenic strain CcS-16 carries 12.5% genes from the mouse strain STS/A on genetic background of the strain BALB/c, and it is more susceptible than BALB/c. In F2 hybrids between BALB/c and CcS-16 we detected and mapped eight gene-loci, Ltr1-8 (Leishmania tropica response 1-8) that control various manifestations of disease: skin lesions, splenomegaly, hepatomegaly, parasite numbers in spleen, liver, and inguinal lymph nodes, and serum level of CCL3, CCL5, and CCL7 after L. tropica infection. These loci are functionally heterogeneous - each influences a different set of responses to the pathogen. Five loci co-localize with the previously described loci that control susceptibility to L. major, three are species-specific. Ltr2 co-localizes not only with Lmr14 (Leishmania major response 14), but also with Ir2 influencing susceptibility to L. donovani and might therefore carry a common gene controlling susceptibility to leishmaniasis.
dcterms:title
Mapping the genes for susceptibility and response to Leishmania tropica in mouse Mapping the genes for susceptibility and response to Leishmania tropica in mouse
skos:prefLabel
Mapping the genes for susceptibility and response to Leishmania tropica in mouse Mapping the genes for susceptibility and response to Leishmania tropica in mouse
skos:notation
RIV/68378050:_____/13:00423385!RIV14-GA0-68378050
n6:predkladatel
n19:ico%3A68378050
n3:aktivita
n5:P n5:I
n3:aktivity
I, P(GA310/08/1697), P(LH12049)
n3:cisloPeriodika
7
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n12:6111122 n12:8665869 n12:3793397 n12:3714896 n12:7092482 n12:5279097 n12:2463490 Sohrabi, Yahya n12:8786119
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
86277
n3:idVysledku
RIV/68378050:_____/13:00423385
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Leishmania tropica; gene controlling susceptibility; host-parasite interactions; leishmaniasis
n3:klicoveSlovo
n14:Leishmania%20tropica n14:leishmaniasis n14:gene%20controlling%20susceptibility n14:host-parasite%20interactions
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[41E9151EFF13]
n3:nazevZdroje
PLoS Neglected Tropical Diseases
n3:obor
n8:EB
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
12
n3:projekt
n15:LH12049 n15:GA310%2F08%2F1697
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
7
n3:tvurceVysledku
Vojtíšková, Jarmila Kobets, Tetyana Jarošíková, T. Svobodová, M. Sohrabi, Yahya Lipoldová, Marie Šíma, Matyáš Demant, P. Volkova, Valeriya Kurey, Irina Havelková, Helena Grekov, Igor
n3:wos
000322321500008
s:issn
1935-2735
s:numberOfPages
17
n18:doi
10.1371/journal.pntd.0002282