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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F13%3A00397212%21RIV14-GA0-68378050
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Methods: TBE virus growth, neutralizing antibody response, key cytokine and chemokine mRNA production and changes in mRNA levels of cell surface markers of immunocompetent cells in brain were measured in mice with different susceptibilities to TBE virus infection. Results: An animal model of TBE based on BALB/c-c-STS/A (CcS/Dem) recombinant congenic mouse strains showing different severities of the infection in relation to the host genetic background was developed. After subcutaneous inoculation of TBE virus, BALB/c mice showed medium susceptibility to the infection, STS mice were resistant, and CcS-11 mice were highly susceptible. The resistant STS mice showed lower and delayed viremia, lower virus production in the brain and low cytokine/chemokine mRNA production, but had a strong neutralizing antibody response. The most sensitive strain (CcS-11) failed in production of neutralizing antibodies, but exhibited strong cytokine/chemokine mRNA production in the brain. After intracerebral inoculation, all mouse strains were sensitive to the infection and had similar virus production in the brain, but STS mice survived significantly longer than CcS-11 mice. These two strains also differed in the expression of key cytokines/chemokines, particularly interferon gamma-induced protein 10 (IP-10/CXCL10) and monocyte chemotactic protein-1 (MCP-1/CCL2) in the brain. Conclusions: Our data indicate that the genetic control is an important factor influencing the clinical course of TBE. High neutralizing antibody response might be crucial for preventing host fatality, but high expression of various cytokines/chemokines during TBE can mediate immunopathology and be associated with more severe course of the infection and increased fatality. Methods: TBE virus growth, neutralizing antibody response, key cytokine and chemokine mRNA production and changes in mRNA levels of cell surface markers of immunocompetent cells in brain were measured in mice with different susceptibilities to TBE virus infection. Results: An animal model of TBE based on BALB/c-c-STS/A (CcS/Dem) recombinant congenic mouse strains showing different severities of the infection in relation to the host genetic background was developed. After subcutaneous inoculation of TBE virus, BALB/c mice showed medium susceptibility to the infection, STS mice were resistant, and CcS-11 mice were highly susceptible. The resistant STS mice showed lower and delayed viremia, lower virus production in the brain and low cytokine/chemokine mRNA production, but had a strong neutralizing antibody response. The most sensitive strain (CcS-11) failed in production of neutralizing antibodies, but exhibited strong cytokine/chemokine mRNA production in the brain. After intracerebral inoculation, all mouse strains were sensitive to the infection and had similar virus production in the brain, but STS mice survived significantly longer than CcS-11 mice. These two strains also differed in the expression of key cytokines/chemokines, particularly interferon gamma-induced protein 10 (IP-10/CXCL10) and monocyte chemotactic protein-1 (MCP-1/CCL2) in the brain. Conclusions: Our data indicate that the genetic control is an important factor influencing the clinical course of TBE. High neutralizing antibody response might be crucial for preventing host fatality, but high expression of various cytokines/chemokines during TBE can mediate immunopathology and be associated with more severe course of the infection and increased fatality.
dcterms:title
Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
skos:prefLabel
Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
skos:notation
RIV/68378050:_____/13:00397212!RIV14-GA0-68378050
n16:predkladatel
n18:ico%3A68378050
n3:aktivita
n5:V n5:I n5:P
n3:aktivity
I, P(ED0006/01/01), P(GAP502/11/2116), V
n3:cisloPeriodika
JUN 2013
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n11:6111122 n11:2463490
n3:druhVysledku
n12:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
88116
n3:idVysledku
RIV/68378050:_____/13:00397212
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Tick-borne encephalitis; Flavivirus encephalitis; Neuroinflammation; Antibody production
n3:klicoveSlovo
n4:Flavivirus%20encephalitis n4:Antibody%20production n4:Neuroinflammation n4:Tick-borne%20encephalitis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B7F60B489260]
n3:nazevZdroje
Journal of Neuroinflammation
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n13:ED0006%2F01%2F01 n13:GAP502%2F11%2F2116
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
10
n3:tvurceVysledku
Grubhoffer, Libor Lipoldová, Marie Palus, Martin Vojtíšková, Jarmila Růžek, Daniel Demant, P. Salát, Jiří Kopecký, Jan
n3:wos
000321275900001
s:issn
1742-2094
s:numberOfPages
13
n15:doi
10.1186/1742-2094-10-77