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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F12%3A00375938%21RIV13-GA0-68378050
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions. Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions.
dcterms:title
The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population
skos:prefLabel
The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population
skos:notation
RIV/68378050:_____/12:00375938!RIV13-GA0-68378050
n9:predkladatel
n19:ico%3A68378050
n3:aktivita
n15:S n15:P n15:Z
n3:aktivity
P(1M0506), P(GAP301/11/1568), P(GAP304/11/0653), P(GD310/08/H077), P(KAN200520804), S, Z(AV0Z50520514), Z(MSM0021620858)
n3:cisloPeriodika
6
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n7:6947891 n7:9565612 n7:2767198 n7:7357354 n7:5695678 n7:5865689 n7:2523329
n3:druhVysledku
n13:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
166033
n3:idVysledku
RIV/68378050:_____/12:00375938
n3:jazykVysledku
n10:eng
n3:klicovaSlova
mesenchymal stem cells; immunomodulation; T-cell development
n3:klicoveSlovo
n18:T-cell%20development n18:mesenchymal%20stem%20cells n18:immunomodulation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3DA972C888C9]
n3:nazevZdroje
Stem Cells and Development
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n4:1M0506 n4:GAP301%2F11%2F1568 n4:GAP304%2F11%2F0653 n4:GD310%2F08%2FH077 n4:KAN200520804
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
21
n3:tvurceVysledku
Procházková, Jana Trošan, Peter Svobodová, Eliška Pokorná, Kateřina Zajícová, Alena Holáň, Vladimír Krulová, Magdalena
n3:wos
000302222700008
n3:zamer
n5:MSM0021620858 n5:AV0Z50520514
s:issn
1547-3287
s:numberOfPages
10
n16:doi
10.1089/scd.2011.0157