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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F11%3A00371708%21RIV12-AV0-68378050
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widely used model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription. Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widely used model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription.
dcterms:title
T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner
skos:prefLabel
T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner
skos:notation
RIV/68378050:_____/11:00371708!RIV12-AV0-68378050
n16:predkladatel
n17:ico%3A68378050
n3:aktivita
n12:P n12:Z
n3:aktivity
P(1M0506), Z(AV0Z50520514)
n3:cisloPeriodika
12-13
n3:dodaniDat
n8:2012
n3:domaciTvurceVysledku
n5:9022643 n5:8435553 n5:9013431 n5:6099017
n3:druhVysledku
n7:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
234264
n3:idVysledku
RIV/68378050:_____/11:00371708
n3:jazykVysledku
n4:eng
n3:klicovaSlova
TNFRSF21; T cells; Jurkat
n3:klicoveSlovo
n10:Jurkat n10:TNFRSF21 n10:T%20cells
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[9F3A07B3D416]
n3:nazevZdroje
Molecular Immunology
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n9:1M0506
n3:rokUplatneniVysledku
n8:2011
n3:svazekPeriodika
48
n3:tvurceVysledku
Broučková, Adéla Klíma, Martin Koc, Michal Anděra, Ladislav
n3:wos
000292444100011
n3:zamer
n19:AV0Z50520514
s:issn
0161-5890
s:numberOfPages
9
n20:doi
10.1016/j.molimm.2011.03.021