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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F11%3A00366961%21RIV12-MZ0-68378050
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The present study examined whether metformin would improve cardiac function and survival also in non-diabetic heart failure of male Wistar rats. Metformin therapy normalized serum NEFAs, decreased myocardial glucose oxidation, increased myocardial palmitate oxidation, but it had no effect on myocardial gene expression, AMPK (AMP-activated protein kinase) signalling, ATP level, mitochondrial respiration, cardiac morphology, function and long-term survival, despite reaching therapeutic serum levels in rats with creating aortocaval fistula. In conclusion, metformin-induced enhancement of myocardial fatty acid oxidation had a neutral effect on cardiac function and survival. Reported cardioprotective effects of metformin may not be universal to all forms of heart failure and may require AMPK activation or ATP depletion. No increase in mortality on metformin supports its safe use in diabetic heart failure The present study examined whether metformin would improve cardiac function and survival also in non-diabetic heart failure of male Wistar rats. Metformin therapy normalized serum NEFAs, decreased myocardial glucose oxidation, increased myocardial palmitate oxidation, but it had no effect on myocardial gene expression, AMPK (AMP-activated protein kinase) signalling, ATP level, mitochondrial respiration, cardiac morphology, function and long-term survival, despite reaching therapeutic serum levels in rats with creating aortocaval fistula. In conclusion, metformin-induced enhancement of myocardial fatty acid oxidation had a neutral effect on cardiac function and survival. Reported cardioprotective effects of metformin may not be universal to all forms of heart failure and may require AMPK activation or ATP depletion. No increase in mortality on metformin supports its safe use in diabetic heart failure
dcterms:title
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats
skos:prefLabel
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats
skos:notation
RIV/68378050:_____/11:00366961!RIV12-MZ0-68378050
n15:predkladatel
n16:ico%3A68378050
n3:aktivita
n10:P n10:Z
n3:aktivity
P(1M0510), P(1M0520), P(GA305/09/1390), P(LC06044), P(NS10300), P(NS10497), P(NS9757), Z(AV0Z50110509), Z(AV0Z50200510), Z(AV0Z50520514), Z(MSM0021620806), Z(MZ0IKEM2005)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n12:3105849 n12:8255806
n3:druhVysledku
n11:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
196351
n3:idVysledku
RIV/68378050:_____/11:00366961
n3:jazykVysledku
n13:eng
n3:klicovaSlova
AMP-activated protein kinase; energy metabolism; heart failure; metformin; survival; volume overload
n3:klicoveSlovo
n8:volume%20overload n8:AMP-activated%20protein%20kinase n8:metformin n8:heart%20failure n8:survival n8:energy%20metabolism
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2A8F8271BC71]
n3:nazevZdroje
Clinical Science and Clinical Science and Molecular Medicine
n3:obor
n19:FA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
16
n3:projekt
n4:1M0510 n4:NS9757 n4:LC06044 n4:NS10497 n4:1M0520 n4:NS10300 n4:GA305%2F09%2F1390
n3:rokUplatneniVysledku
n17:2011
n3:svazekPeriodika
121
n3:tvurceVysledku
Strnad, Hynek Vrbacký, Marek Melenovsky, V. Červenka, L. Houštěk, Josef Petrák, J. Kolář, Michal Sedmera, David Medříková, Daša Kopecký, Jan Kazdová, L. Kovářová, Nikola Drahota, Zdeněk Beneš, J. Škaroupková, P. Benada, Oldřich
n3:wos
000293155200004
n3:zamer
n5:MZ0IKEM2005 n5:AV0Z50110509 n5:AV0Z50200510 n5:MSM0021620806 n5:AV0Z50520514
s:issn
0143-5221
s:numberOfPages
13
n14:doi
10.1042/CS20100527