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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F11%3A00365189%21RIV12-AV0-68378050
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Multipotent mesenchymal stem cells can participate in the formation of a microenvironment stimulating the aggressive behaviour of cancer cells. Cells exhibiting pluripotent embryonic stem cell markers (Nanog and Oct4) have been observed in many tumours. Here, we investigate the stem cell supporting role of cancer-associated fibroblasts (CAF). We test the influence of CAF isolated from basal cell carcinoma on mouse 3T3 fibroblasts, focusing on the expression of stem cell markers and plasticity in vitro. We demonstrate the biological activity of CAF by influencing the 3T3 fibroblasts to express markers such as Oct4, Nanog and Sox2 and to show differentiation potential similar to mesenchymal stem cells. The role of growth factors such as IGF2, FGF7, LEP, NGF and TGFβ, produced by CAF, is established to participate in their activity. Our observations indicate the pro-stem cell activity of CAF and underline the role of epithelial–mesenchymal interaction in tumour biology. Multipotent mesenchymal stem cells can participate in the formation of a microenvironment stimulating the aggressive behaviour of cancer cells. Cells exhibiting pluripotent embryonic stem cell markers (Nanog and Oct4) have been observed in many tumours. Here, we investigate the stem cell supporting role of cancer-associated fibroblasts (CAF). We test the influence of CAF isolated from basal cell carcinoma on mouse 3T3 fibroblasts, focusing on the expression of stem cell markers and plasticity in vitro. We demonstrate the biological activity of CAF by influencing the 3T3 fibroblasts to express markers such as Oct4, Nanog and Sox2 and to show differentiation potential similar to mesenchymal stem cells. The role of growth factors such as IGF2, FGF7, LEP, NGF and TGFβ, produced by CAF, is established to participate in their activity. Our observations indicate the pro-stem cell activity of CAF and underline the role of epithelial–mesenchymal interaction in tumour biology.
dcterms:title
Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells
skos:prefLabel
Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells
skos:notation
RIV/68378050:_____/11:00365189!RIV12-AV0-68378050
n3:predkladatel
n11:ico%3A68378050
n4:aktivita
n19:Z n19:I n19:S n19:P
n4:aktivity
I, P(1M0520), P(1M0538), P(2B06106), S, Z(AV0Z50520514), Z(MSM0021620806)
n4:cisloPeriodika
5
n4:dodaniDat
n16:2012
n4:domaciTvurceVysledku
n8:8255806 n8:3105849 n8:6294561 n8:6662102
n4:druhVysledku
n20:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
213853
n4:idVysledku
RIV/68378050:_____/11:00365189
n4:jazykVysledku
n5:eng
n4:klicovaSlova
basal cell carcinoma (BCC); stem cell; tumour stroma
n4:klicoveSlovo
n13:tumour%20stroma n13:stem%20cell n13:basal%20cell%20carcinoma%20%28BCC%29
n4:kodStatuVydavatele
FR - Francouzská republika
n4:kontrolniKodProRIV
[A810AFA4C570]
n4:nazevZdroje
Biology of the Cell
n4:obor
n12:EB
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
9
n4:projekt
n15:1M0520 n15:1M0538 n15:2B06106
n4:rokUplatneniVysledku
n16:2011
n4:svazekPeriodika
103
n4:tvurceVysledku
Vlček, Čestmír Szabo, Pavol Kolář, Michal Smetana, K. Dvořánková, B. Tvrdek, M. Strnad, Hynek Lacina, L. Štork, J.
n4:wos
000292430900003
n4:zamer
n7:AV0Z50520514 n7:MSM0021620806
s:issn
0248-4900
s:numberOfPages
16
n6:doi
10.1042/BC20100113