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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F11%3A00365117%21RIV12-AV0-68378050
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva. Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva.
dcterms:title
The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure
skos:prefLabel
The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure
skos:notation
RIV/68378050:_____/11:00365117!RIV12-AV0-68378050
n10:predkladatel
n11:ico%3A68378050
n3:aktivita
n20:S n20:P n20:Z
n3:aktivity
P(GA206/09/0777), P(GA206/09/0822), P(LC06009), S, Z(AV0Z50520514), Z(MSM0021620828)
n3:cisloPeriodika
5
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n7:8665869 n7:6111122
n3:druhVysledku
n14:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
224808
n3:idVysledku
RIV/68378050:_____/11:00365117
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Phlebotomus duboscqi; Leishmania major; anti-saliva IgG
n3:klicoveSlovo
n9:anti-saliva%20IgG n9:Leishmania%20major n9:Phlebotomus%20duboscqi
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[60AB8E4D03CB]
n3:nazevZdroje
International Journal for Parasitology
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n5:LC06009 n5:GA206%2F09%2F0777 n5:GA206%2F09%2F0822
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
41
n3:tvurceVysledku
Kobets, Tetyana Volf, P. Hostomská, J. Rohoušová, I. Vlková, M. Lipoldová, Marie
n3:wos
000289402300002
n3:zamer
n13:MSM0021620828 n13:AV0Z50520514
s:issn
0020-7519
s:numberOfPages
5
n18:doi
10.1016/j.ijpara.2011.01.003