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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F11%3A00363620%21RIV12-AV0-68378050
rdf:type
skos:Concept n5:Vysledek
dcterms:description
Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes. Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes.
dcterms:title
Genetic control of resistance to Trypanosoma brucei brucei infection in mice Genetic control of resistance to Trypanosoma brucei brucei infection in mice
skos:prefLabel
Genetic control of resistance to Trypanosoma brucei brucei infection in mice Genetic control of resistance to Trypanosoma brucei brucei infection in mice
skos:notation
RIV/68378050:_____/11:00363620!RIV12-AV0-68378050
n5:predkladatel
n6:ico%3A68378050
n4:aktivita
n16:V n16:Z n16:P
n4:aktivity
P(IAA500520606), P(LC06009), V, Z(AV0Z50520514), Z(MSM0021620828)
n4:cisloPeriodika
6
n4:dodaniDat
n10:2012
n4:domaciTvurceVysledku
n7:2463490 n7:7092482 n7:6111122 n7:8786119
n4:druhVysledku
n20:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
200985
n4:idVysledku
RIV/68378050:_____/11:00363620
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Trypanosoma brucei brucei; mouse recombinant congenic strains; Tbbr
n4:klicoveSlovo
n8:Tbbr n8:mouse%20recombinant%20congenic%20strains n8:Trypanosoma%20brucei%20brucei
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[E31C9EFA2113]
n4:nazevZdroje
PLoS Neglected Tropical Diseases
n4:obor
n13:EB
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
9
n4:projekt
n14:IAA500520606 n14:LC06009
n4:rokUplatneniVysledku
n10:2011
n4:svazekPeriodika
5
n4:tvurceVysledku
Šíma, Matyáš Lipoldová, Marie Svobodová, M. Stassen, A. P. M. Quan, L. Havelková, Helena Jarošíková, T. Vojtíšková, Jarmila Demant, P.
n4:wos
000292139600018
n4:zamer
n9:AV0Z50520514 n9:MSM0021620828
s:issn
1935-2735
s:numberOfPages
12
n19:doi
10.1371/journal.pntd.0001173