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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F11%3A00355310%21RIV12-AV0-68378050
rdf:type
skos:Concept n3:Vysledek
dcterms:description
A new model of orthotopic limbal transplantation was established in the mouse. The survival of limbal autografts, allografts and xenografts was characterized according to the clinical criteria, and intragraft cytokine response was determined by a real-time PCR. The results showed that the limbal grafts do not enjoy immune privilege of the eye and are promptly rejected by Th1 or combined Th1 and Th2 type of immune response involving CD4 pozitive cells and iNOS expression. Targeting this pathway may be an effective way to prevent and treat limbal graft rejection. A new model of orthotopic limbal transplantation was established in the mouse. The survival of limbal autografts, allografts and xenografts was characterized according to the clinical criteria, and intragraft cytokine response was determined by a real-time PCR. The results showed that the limbal grafts do not enjoy immune privilege of the eye and are promptly rejected by Th1 or combined Th1 and Th2 type of immune response involving CD4 pozitive cells and iNOS expression. Targeting this pathway may be an effective way to prevent and treat limbal graft rejection.
dcterms:title
Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model
skos:prefLabel
Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model
skos:notation
RIV/68378050:_____/11:00355310!RIV12-AV0-68378050
n3:predkladatel
n4:ico%3A68378050
n5:aktivita
n18:Z n18:P
n5:aktivity
P(1M0506), P(GD310/08/H077), P(KAN200520804), Z(AV0Z50520514), Z(MSM0021620806), Z(MSM0021620858)
n5:cisloPeriodika
3
n5:dodaniDat
n10:2012
n5:domaciTvurceVysledku
n6:3066266 n6:5865689 n6:5695678 n6:6947891 n6:9565612
n5:druhVysledku
n20:J
n5:duvernostUdaju
n19:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
201482
n5:idVysledku
RIV/68378050:_____/11:00355310
n5:jazykVysledku
n15:eng
n5:klicovaSlova
limbal transplantation; graft survival; cytokine response
n5:klicoveSlovo
n12:limbal%20transplantation n12:graft%20survival n12:cytokine%20response
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[531BBFC0A7DD]
n5:nazevZdroje
Transplant Immunology
n5:obor
n17:EC
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
6
n5:projekt
n7:GD310%2F08%2FH077 n7:KAN200520804 n7:1M0506
n5:rokUplatneniVysledku
n10:2011
n5:svazekPeriodika
24
n5:tvurceVysledku
Krulová, Magdalena Lenčová, Anna Zajícová, Alena Filipec, M. Holáň, Vladimír Pokorná, Kateřina
n5:wos
000288478500008
n5:zamer
n14:AV0Z50520514 n14:MSM0021620858 n14:MSM0021620806
s:issn
0966-3274
s:numberOfPages
6
n9:doi
10.1016/j.trim.2010.11.005