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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00391344%21RIV13-MZ0-68378050
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article. Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis. Evasion of endogenous cell death processes, including apoptosis, represents one of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic agents may be, in some cases, caused by dysregulation of apoptotic pathways, e.g. BCL2 or IAP overexpression. The understanding of the physiological mechanisms that control apoptosis and the elucidation of apoptotic defects in cancer cells may lead to the development of targeted cancer therapies. Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis pathways and promising new anti-cancer agents, which trigger directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article.
dcterms:title
The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies
skos:prefLabel
The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies
skos:notation
RIV/68378050:_____/10:00391344!RIV13-MZ0-68378050
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1M0506), P(LC06044), P(NR8317), P(NR8930), P(NS10287), Z(AV0Z50520514), Z(MSM0021620806), Z(MSM0021620808)
n3:cisloPeriodika
1
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n15:9022643
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
285678
n3:idVysledku
RIV/68378050:_____/10:00391344
n3:jazykVysledku
n10:eng
n3:klicovaSlova
apoptosis; cancer therapy; leukemia
n3:klicoveSlovo
n12:apoptosis n12:cancer%20therapy n12:leukemia
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[E71AB2FCE7C3]
n3:nazevZdroje
Current Pharmaceutical Design
n3:obor
n9:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n6:LC06044 n6:1M0506 n6:NS10287 n6:NR8930 n6:NR8317
n3:rokUplatneniVysledku
n7:2010
n3:svazekPeriodika
16
n3:tvurceVysledku
Klener, P. Pytlík, R. Živný, J. Anděra, Ladislav
n3:wos
000272773200003
n3:zamer
n16:AV0Z50520514 n16:MSM0021620808 n16:MSM0021620806
s:issn
1381-6128
s:numberOfPages
23