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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00355306%21RIV11-AV0-68378050
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The immunosuppression hypothesis suggests that the increased sex ratio in mice and women with latent toxoplasmosis, retarded embryonic growth in the early phases of pregnancy, prolonged pregnancy of Toxoplasma-infected women, and increased prevalence of toxoplasmosis in mothers of children with Down syndrome can be explained by the presumed immunosuppressive effects of latent toxoplasmosis. Here, we searched for indices of immunosuppression in mice experimentally infected with Toxoplasma gondii. Our results showed that mice in the early phase of latent infection exhibited temporarily increased production of interleukin (IL)-12 and decreased production of IL-10. In accordance with the immunosuppression hypothesis, the mice showed decreased production of IL-2 and nitric oxide and decreased proliferation reaction (synthesis of DNA) in the mixed lymphocyte culture in the early and also in the late phases of latent toxoplasmosis. The immunosuppression hypothesis suggests that the increased sex ratio in mice and women with latent toxoplasmosis, retarded embryonic growth in the early phases of pregnancy, prolonged pregnancy of Toxoplasma-infected women, and increased prevalence of toxoplasmosis in mothers of children with Down syndrome can be explained by the presumed immunosuppressive effects of latent toxoplasmosis. Here, we searched for indices of immunosuppression in mice experimentally infected with Toxoplasma gondii. Our results showed that mice in the early phase of latent infection exhibited temporarily increased production of interleukin (IL)-12 and decreased production of IL-10. In accordance with the immunosuppression hypothesis, the mice showed decreased production of IL-2 and nitric oxide and decreased proliferation reaction (synthesis of DNA) in the mixed lymphocyte culture in the early and also in the late phases of latent toxoplasmosis.
dcterms:title
Modulation of immunity in mice with latent toxoplasmosis-the experimental support for the immunosuppression hypothesis of Toxoplasma-induced changes in reproduction of mice and humans Modulation of immunity in mice with latent toxoplasmosis-the experimental support for the immunosuppression hypothesis of Toxoplasma-induced changes in reproduction of mice and humans
skos:prefLabel
Modulation of immunity in mice with latent toxoplasmosis-the experimental support for the immunosuppression hypothesis of Toxoplasma-induced changes in reproduction of mice and humans Modulation of immunity in mice with latent toxoplasmosis-the experimental support for the immunosuppression hypothesis of Toxoplasma-induced changes in reproduction of mice and humans
skos:notation
RIV/68378050:_____/10:00355306!RIV11-AV0-68378050
n4:aktivita
n13:Z
n4:aktivity
Z(AV0Z50520514), Z(MSM0021620828), Z(MSM0021620858)
n4:cisloPeriodika
2010
n4:dodaniDat
n16:2011
n4:domaciTvurceVysledku
n11:6947891
n4:druhVysledku
n12:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n5:predkladatel
n4:idSjednocenehoVysledku
272335
n4:idVysledku
RIV/68378050:_____/10:00355306
n4:jazykVysledku
n9:eng
n4:klicovaSlova
sex ratio; manipulation; women
n4:klicoveSlovo
n7:sex%20ratio n7:women n7:manipulation
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[69C529EC350F]
n4:nazevZdroje
Parasitology Research
n4:obor
n17:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n16:2010
n4:svazekPeriodika
107
n4:tvurceVysledku
Zajícová, Alena Kaňková, Š. Holáň, V. Kodym, P. Flegr, J.
n4:wos
000284072400017
n4:zamer
n6:AV0Z50520514 n6:MSM0021620858 n6:MSM0021620828
s:issn
0932-0113
s:numberOfPages
7