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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00355121%21RIV11-MSM-68378050
rdf:type
n10:Vysledek skos:Concept
dcterms:description
During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion. During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion.
dcterms:title
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
skos:prefLabel
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
skos:notation
RIV/68378050:_____/10:00355121!RIV11-MSM-68378050
n3:aktivita
n13:Z n13:P
n3:aktivity
P(GA202/08/0590), P(LC06061), Z(AV0Z50520514), Z(MSM0021620858)
n3:cisloPeriodika
22
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n14:2631334
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
285770
n3:idVysledku
RIV/68378050:_____/10:00355121
n3:jazykVysledku
n16:eng
n3:klicovaSlova
endothelial barrier function; pericellular proteolysis; melanoma cells
n3:klicoveSlovo
n8:endothelial%20barrier%20function n8:melanoma%20cells n8:pericellular%20proteolysis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B28785CD15AD]
n3:nazevZdroje
Cell communication and signaling : CCS
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:projekt
n6:LC06061 n6:GA202%2F08%2F0590
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
8
n3:tvurceVysledku
Fabry, B. Rosel, D. Veselý, Pavel Brabek, J. Mierke, C. T.
n3:wos
000282265700003
n3:zamer
n4:MSM0021620858 n4:AV0Z50520514
s:issn
1478-811X
s:numberOfPages
8