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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00354924%21RIV11-GA0-68378050
rdf:type
n8:Vysledek skos:Concept
dcterms:description
DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression and enables DNA repair. Phosphorylated form of the histone H2AX (called gamma-H2AX) serves as an essential platform for recruitment and retention of additional components of the checkpoint signaling cascade (such as MDC1 and 53BP1) in the chromatin region flanking the DSB. Here we demonstrate that the Wip1 phosphatase is bound to chromatin and directly dephosphorylates gamma-H2AX. Cells depleted of Wip1 fail to dephosphorylate gamma-H2AX during checkpoint recovery. Conversely, premature activation of Wip1 leads to displacement of MDC1 from damage foci and prevents activation of the checkpoint. Taken together, our data demonstrate that Wip1 plays an essential role in dephosphorylation of gamma-H2AX in order to silence the checkpoint and restore chromatin structure once DNA damage is repaired. DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression and enables DNA repair. Phosphorylated form of the histone H2AX (called gamma-H2AX) serves as an essential platform for recruitment and retention of additional components of the checkpoint signaling cascade (such as MDC1 and 53BP1) in the chromatin region flanking the DSB. Here we demonstrate that the Wip1 phosphatase is bound to chromatin and directly dephosphorylates gamma-H2AX. Cells depleted of Wip1 fail to dephosphorylate gamma-H2AX during checkpoint recovery. Conversely, premature activation of Wip1 leads to displacement of MDC1 from damage foci and prevents activation of the checkpoint. Taken together, our data demonstrate that Wip1 plays an essential role in dephosphorylation of gamma-H2AX in order to silence the checkpoint and restore chromatin structure once DNA damage is repaired.
dcterms:title
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition
skos:prefLabel
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition
skos:notation
RIV/68378050:_____/10:00354924!RIV11-GA0-68378050
n3:aktivita
n4:Z n4:P
n3:aktivity
P(GPP305/10/P420), Z(AV0Z50520514)
n3:cisloPeriodika
15
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n7:6785417
n3:druhVysledku
n15:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
298863
n3:idVysledku
RIV/68378050:_____/10:00354924
n3:jazykVysledku
n16:eng
n3:klicovaSlova
DNA damage; checkpoint; phosphatase
n3:klicoveSlovo
n13:DNA%20damage n13:phosphatase n13:checkpoint
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[C2B750087B06]
n3:nazevZdroje
Oncogene
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n17:GPP305%2F10%2FP420
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
29
n3:tvurceVysledku
Lindqvist, A. Macůrek, Libor Kool, J. Voets, O. Medema, R. H. Vos, H. R.
n3:wos
000276685200013
n3:zamer
n11:AV0Z50520514
s:issn
0950-9232
s:numberOfPages
11