This HTML5 document contains 44 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n8http://linked.opendata.cz/resource/domain/vavai/projekt/
n11http://linked.opendata.cz/ontology/domain/vavai/
n14http://linked.opendata.cz/resource/domain/vavai/zamer/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F68378050%3A_____%2F10%3A00349854%21RIV11-GA0-68378050/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n13http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n12http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00349854%21RIV11-GA0-68378050
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Membrane rafts are microdomains involved in a number of biologically important processes, including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins, containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays important roles in signal initiation by several other immunologically important receptors. Here we review recent progress in the elucidation of several aspects of this protein, e.g. the controversy concerning the importance of LAT being present in membrane rafts, the involvement in signalling through a number of receptors other than the T cell receptor and the puzzling phenotype of some LAT mutants. Membrane rafts are microdomains involved in a number of biologically important processes, including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins, containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays important roles in signal initiation by several other immunologically important receptors. Here we review recent progress in the elucidation of several aspects of this protein, e.g. the controversy concerning the importance of LAT being present in membrane rafts, the involvement in signalling through a number of receptors other than the T cell receptor and the puzzling phenotype of some LAT mutants.
dcterms:title
LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic
skos:prefLabel
LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic
skos:notation
RIV/68378050:_____/10:00349854!RIV11-GA0-68378050
n3:aktivita
n7:Z n7:P
n3:aktivity
P(1M0506), P(GEMEM/09/E011), Z(AV0Z50520514)
n3:cisloPeriodika
21
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n10:1402889 n10:7171390 n10:7776535
n3:druhVysledku
n9:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
267983
n3:idVysledku
RIV/68378050:_____/10:00349854
n3:jazykVysledku
n17:eng
n3:klicovaSlova
LAT; transmembrane adaptor protein; membrane rafts
n3:klicoveSlovo
n13:LAT n13:membrane%20rafts n13:transmembrane%20adaptor%20protein
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8F1AE3B2643F]
n3:nazevZdroje
FEBS Journal
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n8:GEMEM%2F09%2FE011 n8:1M0506
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
277
n3:tvurceVysledku
Hořejší, Václav Otáhal, Pavel Brdička, Tomáš
n3:wos
000282821200006
n3:zamer
n14:AV0Z50520514
s:issn
1742-464X
s:numberOfPages
15