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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00347088%21RIV11-MSM-68378050
rdf:type
skos:Concept n12:Vysledek
dcterms:description
The discovery of circulating nucleic acids in the 1940s opened up new possibilities for the non-invasive detection, monitoring and screening of various human disorders. Several tumour markers that enable early cancer detection or tumour behaviour prediction have been detected in the plasma of cancer patients. Maternal plasma analysis can be used to detect certain fetal abnormalities, with the quantification of cell-free nucleic acids used to screen for several pregnancy-associated disorders. Some other applications are in transplant monitoring and graft rejection assessment, and in certain medical emergencies such as trauma and burn severity stratification. Many studies have yielded promising results in this field, but the techniques have yet to be applied in routine clinical practice. Large-scale studies using similar technologies and a broad spectrum of patients are still needed to verify the results of the various studies. The discovery of circulating nucleic acids in the 1940s opened up new possibilities for the non-invasive detection, monitoring and screening of various human disorders. Several tumour markers that enable early cancer detection or tumour behaviour prediction have been detected in the plasma of cancer patients. Maternal plasma analysis can be used to detect certain fetal abnormalities, with the quantification of cell-free nucleic acids used to screen for several pregnancy-associated disorders. Some other applications are in transplant monitoring and graft rejection assessment, and in certain medical emergencies such as trauma and burn severity stratification. Many studies have yielded promising results in this field, but the techniques have yet to be applied in routine clinical practice. Large-scale studies using similar technologies and a broad spectrum of patients are still needed to verify the results of the various studies.
dcterms:title
Circulating nucleic acids as a new diagnostic tool Circulating nucleic acids as a new diagnostic tool
skos:prefLabel
Circulating nucleic acids as a new diagnostic tool Circulating nucleic acids as a new diagnostic tool
skos:notation
RIV/68378050:_____/10:00347088!RIV11-MSM-68378050
n3:aktivita
n4:S n4:P n4:Z n4:I
n3:aktivity
I, P(2B06106), S, Z(AV0Z50520514)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n6:3468097 n6:3105849
n3:druhVysledku
n8:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
250820
n3:idVysledku
RIV/68378050:_____/10:00347088
n3:jazykVysledku
n17:eng
n3:klicovaSlova
circulating nucleic acids; diagnostics; cancer
n3:klicoveSlovo
n11:diagnostics n11:cancer n11:circulating%20nucleic%20acids
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[C79D4CE2DDEF]
n3:nazevZdroje
Cellular & Molecular Biology Letters
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n13:2B06106
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
15
n3:tvurceVysledku
Urbanová, Markéta Strnad, Hynek Plzák, J. Betka, J.
n3:wos
000275966600005
n3:zamer
n14:AV0Z50520514
s:issn
1425-8153
s:numberOfPages
18