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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00346785%21RIV11-GA0-68378050
rdf:type
n16:Vysledek skos:Concept
dcterms:description
We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs. We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs.
dcterms:title
Immunoregulatory properties of mouse limbal stem cells Immunoregulatory properties of mouse limbal stem cells
skos:prefLabel
Immunoregulatory properties of mouse limbal stem cells Immunoregulatory properties of mouse limbal stem cells
skos:notation
RIV/68378050:_____/10:00346785!RIV11-GA0-68378050
n3:aktivita
n17:Z n17:P
n3:aktivity
P(1M0506), P(GD310/08/H077), P(KAN200520804), Z(AV0Z50520514), Z(MSM0021620858)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n6:2523329 n6:5865689 n6:6947891 n6:5695678
n3:druhVysledku
n7:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
262917
n3:idVysledku
RIV/68378050:_____/10:00346785
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Limbal stem cells; immunoregulation; apoptosis
n3:klicoveSlovo
n8:apoptosis n8:immunoregulation n8:Limbal%20stem%20cells
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9586F8D4509C]
n3:nazevZdroje
Journal of Immunology
n3:obor
n18:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n9:KAN200520804 n9:GD310%2F08%2FH077 n9:1M0506
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
184
n3:tvurceVysledku
Zajícová, Alena Pokorná, Kateřina Krulová, M. Procházková, Jana Holáň, Vladimír
n3:wos
000274585100047
n3:zamer
n4:MSM0021620858 n4:AV0Z50520514
s:issn
0022-1767
s:numberOfPages
6