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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F10%3A00334121%21RIV10-MSM-68378050
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth. Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth.
dcterms:title
Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility
skos:prefLabel
Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility
skos:notation
RIV/68378050:_____/10:00334121!RIV10-MSM-68378050
n3:aktivita
n9:Z n9:P
n3:aktivity
P(GD310/08/H077), P(IAA500520606), P(LC06009), Z(AV0Z50520514)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n4:7092482 n4:6111122 n4:9565612 n4:2463490 n4:8506051 Sohrabi, Yahya
n3:druhVysledku
n17:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
268776
n3:idVysledku
RIV/68378050:_____/10:00334121
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Tumor susceptibility; Genetic control of interferon gamma production; Lymphocyte infiltration of tumors
n3:klicoveSlovo
n11:Genetic%20control%20of%20interferon%20gamma%20production n11:Tumor%20susceptibility n11:Lymphocyte%20infiltration%20of%20tumors
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[514FCA4AB3BD]
n3:nazevZdroje
Cancer Immunology and Immunotherapy
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:projekt
n5:IAA500520606 n5:GD310%2F08%2FH077 n5:LC06009
n3:rokUplatneniVysledku
n16:2010
n3:svazekPeriodika
59
n3:tvurceVysledku
Sohrabi, Yahya Stassen, A. P. M. Demant, P. Havelková, Helena Vojtíšková, Jarmila Quan, L. Krulová, Magdalena Lipoldová, Marie Badalová, Jana
n3:wos
000271748600003
n3:zamer
n10:AV0Z50520514
s:issn
0340-7004
s:numberOfPages
11