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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F09%3A00334127%21RIV10-MSM-68378050
rdf:type
n9:Vysledek skos:Concept
dcterms:description
In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog, house dust mites), total IgE overproduction and airway hyperreactivity. Definition of genes predisposing to development of various subcomponents of asthma phenotype is important for understanding etiology of this disease. We tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear families with asthma from Siberia. The most significant linkage was to the candidate region on chromosome 12. Locus controlling cat-specific IgE was mapped within the interval 136-140 cM on chromosome 12q24.3. Total IgE was also linked to this region. FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus but more proximally. Some evidence of linkage was also detected for asthma at 6p21.31 and total IgE at 13q14.2. Locus 12q24.3 thus seems the most promising candidate for identification of asthma genes in Russian population of Siberia. In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog, house dust mites), total IgE overproduction and airway hyperreactivity. Definition of genes predisposing to development of various subcomponents of asthma phenotype is important for understanding etiology of this disease. We tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear families with asthma from Siberia. The most significant linkage was to the candidate region on chromosome 12. Locus controlling cat-specific IgE was mapped within the interval 136-140 cM on chromosome 12q24.3. Total IgE was also linked to this region. FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus but more proximally. Some evidence of linkage was also detected for asthma at 6p21.31 and total IgE at 13q14.2. Locus 12q24.3 thus seems the most promising candidate for identification of asthma genes in Russian population of Siberia.
dcterms:title
Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
skos:prefLabel
Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
skos:notation
RIV/68378050:_____/09:00334127!RIV10-MSM-68378050
n3:aktivita
n11:Z n11:S n11:P
n3:aktivity
P(GA310/06/1745), P(LC06009), S, Z(AV0Z50520514)
n3:cisloPeriodika
1
n3:dodaniDat
n18:2010
n3:domaciTvurceVysledku
n7:6111122 n7:4745175
n3:druhVysledku
n6:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
307048
n3:idVysledku
RIV/68378050:_____/09:00334127
n3:jazykVysledku
n17:eng
n3:klicovaSlova
IgE; asthma; cat allergens
n3:klicoveSlovo
n4:IgE n4:asthma n4:cat%20allergens
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[B752D60AA37B]
n3:nazevZdroje
Immunology Letters
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n14:GA310%2F06%2F1745 n14:LC06009
n3:rokUplatneniVysledku
n18:2009
n3:svazekPeriodika
125
n3:tvurceVysledku
Buinova, S. N. Chernyak, B. A. Puzyrev, V. P. Lipoldová, Marie Ogorodova, L. M. Gusareva, Elena Bragina, E. J.
n3:wos
000268649300001
n3:zamer
n13:AV0Z50520514
s:issn
0165-2478
s:numberOfPages
6