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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F09%3A00334105%21RIV10-MSM-68378050
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Leishmania major infection in mice is an important model of host-pathogen relationship. Infected BALB/c mice exhibit high parasite numbers in lymph nodes and spleens and chronic disease with skin lesions, splenomegaly, hepatomegaly, increased serum IgE levels and cytokine imbalance. Linkage analysis integrated with study of multiple manifestations of infection in (BALB/c x CcS-11) F2 hybrids mapped 5 loci, 2 of which control parasite elimination or dissemination. Lmr5 influences parasite loads in spleens (+ skin lesions, splenomegaly, serum IgE, IL-4, and IFNg levels) and Lmr20 determines parasite numbers in draining lymph nodes (+ serum IgE and IFNg levels) but no skin or visceral pathology. Three additional loci do not affect parasite numbers but significantly influence disease phenotype - Lmr21: skin lesions, IFNg levels, Lmr22: IL-4 levels, Lmr23: IFNg levels, indicating that L. major-caused disease development includes critical regulations additional to control of parasite spread. Leishmania major infection in mice is an important model of host-pathogen relationship. Infected BALB/c mice exhibit high parasite numbers in lymph nodes and spleens and chronic disease with skin lesions, splenomegaly, hepatomegaly, increased serum IgE levels and cytokine imbalance. Linkage analysis integrated with study of multiple manifestations of infection in (BALB/c x CcS-11) F2 hybrids mapped 5 loci, 2 of which control parasite elimination or dissemination. Lmr5 influences parasite loads in spleens (+ skin lesions, splenomegaly, serum IgE, IL-4, and IFNg levels) and Lmr20 determines parasite numbers in draining lymph nodes (+ serum IgE and IFNg levels) but no skin or visceral pathology. Three additional loci do not affect parasite numbers but significantly influence disease phenotype - Lmr21: skin lesions, IFNg levels, Lmr22: IL-4 levels, Lmr23: IFNg levels, indicating that L. major-caused disease development includes critical regulations additional to control of parasite spread.
dcterms:title
Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection
skos:prefLabel
Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection
skos:notation
RIV/68378050:_____/09:00334105!RIV10-MSM-68378050
n3:aktivita
n7:P n7:Z
n3:aktivity
P(GA310/06/1745), P(LC06009), Z(AV0Z50520514)
n3:cisloPeriodika
9
n3:dodaniDat
n9:2010
n3:domaciTvurceVysledku
n4:5279097 n4:6111122 n4:3714896 n4:7092482 n4:4139151 n4:8665869 n4:1465848
n3:druhVysledku
n18:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
310817
n3:idVysledku
RIV/68378050:_____/09:00334105
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Leishmania major; Parasite elimination; QTL mapping
n3:klicoveSlovo
n13:Parasite%20elimination n13:QTL%20mapping n13:Leishmania%20major
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[C551DC961370]
n3:nazevZdroje
Immunogenetics
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
12
n3:projekt
n5:LC06009 n5:GA310%2F06%2F1745
n3:rokUplatneniVysledku
n9:2009
n3:svazekPeriodika
61
n3:tvurceVysledku
Hutson, A. Kobets, Tetyana Havelková, Helena Demant, P. Svobodová, M. Quan, L. Stassen, A. P. M. Grekov, Igor Slapničková, Martina Lipoldová, Marie Trtková, Kateřina Kurey, Irina
n3:wos
000269853400003
n3:zamer
n12:AV0Z50520514
s:issn
0093-7711
s:numberOfPages
15