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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F09%3A00334054%21RIV10-MSM-68378050
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The small chemical vacuolin-1 induces rapid formation of large vacuoles in various cell types. In epithelial cells, vacuolin-1 has been shown to inhibit Ca2+ ionophore-induced exocytosis depending on experimental conditions used but had no effect on repair of damaged membranes. However, it is not known whether vacuolin-1 could inhibit exocytosis induced by immunoreceptor triggering in professional secretory cells and whether there is any correlation between effect of vacuolin-1 on exocytosis and membrane repair in such cells. Here we show that in rat basophilic leukemia (RBL-2H3) cells activated by the high-affinity IgE receptor (FcepsilonRI) triggering vacuolin-1 enhanced exocytosis. Under identical conditions of activation, vacuolin-1 inhibited exocytosis in mouse bone marrow-derived mast cells. Our data indicate that lysosomal exocytosis exhibits different sensitivity to vacuolin-1 depending on the cell type analyzed and mode of activation. The small chemical vacuolin-1 induces rapid formation of large vacuoles in various cell types. In epithelial cells, vacuolin-1 has been shown to inhibit Ca2+ ionophore-induced exocytosis depending on experimental conditions used but had no effect on repair of damaged membranes. However, it is not known whether vacuolin-1 could inhibit exocytosis induced by immunoreceptor triggering in professional secretory cells and whether there is any correlation between effect of vacuolin-1 on exocytosis and membrane repair in such cells. Here we show that in rat basophilic leukemia (RBL-2H3) cells activated by the high-affinity IgE receptor (FcepsilonRI) triggering vacuolin-1 enhanced exocytosis. Under identical conditions of activation, vacuolin-1 inhibited exocytosis in mouse bone marrow-derived mast cells. Our data indicate that lysosomal exocytosis exhibits different sensitivity to vacuolin-1 depending on the cell type analyzed and mode of activation.
dcterms:title
Vacuolin-1-modulated exocytosis and cell resealing in mast cells Vacuolin-1-modulated exocytosis and cell resealing in mast cells
skos:prefLabel
Vacuolin-1-modulated exocytosis and cell resealing in mast cells Vacuolin-1-modulated exocytosis and cell resealing in mast cells
skos:notation
RIV/68378050:_____/09:00334054!RIV10-MSM-68378050
n3:aktivita
n7:P n7:Z
n3:aktivity
P(1M0506), P(GA301/09/1826), P(LC545), Z(AV0Z50520514), Z(MSM0021620814)
n3:cisloPeriodika
8
n3:dodaniDat
n12:2010
n3:domaciTvurceVysledku
n5:5182581 n5:2765233 n5:6550789 n5:2157675
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
348336
n3:idVysledku
RIV/68378050:_____/09:00334054
n3:jazykVysledku
n18:eng
n3:klicovaSlova
vacuolin-1; exocytosis; mast cells
n3:klicoveSlovo
n6:exocytosis n6:mast%20cells n6:vacuolin-1
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B6E753D6A6B6]
n3:nazevZdroje
Cellular Signalling
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n4:GA301%2F09%2F1826 n4:1M0506 n4:LC545
n3:rokUplatneniVysledku
n12:2009
n3:svazekPeriodika
21
n3:tvurceVysledku
Heneberg, Petr Dráberová, Lubica Dráber, Petr Shaik, Gouse Mohiddin
n3:wos
000267099800011
n3:zamer
n11:AV0Z50520514 n11:MSM0021620814
s:issn
0898-6568
s:numberOfPages
9