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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F09%3A00330753%21RIV10-MSM-68378050
rdf:type
skos:Concept n15:Vysledek
dcterms:description
In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens. In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens.
dcterms:title
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir
skos:prefLabel
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir
skos:notation
RIV/68378050:_____/09:00330753!RIV10-MSM-68378050
n3:aktivita
n9:P n9:Z
n3:aktivity
P(1M0508), Z(AV0Z40550506), Z(AV0Z50520514)
n3:cisloPeriodika
17
n3:dodaniDat
n10:2010
n3:domaciTvurceVysledku
n14:7774729
n3:druhVysledku
n11:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
327220
n3:idVysledku
RIV/68378050:_____/09:00330753
n3:jazykVysledku
n17:eng
n3:klicovaSlova
HIV-1 protease; darunavir; X-ray structural analysis; protease inhibitor; mutations
n3:klicoveSlovo
n8:mutations n8:protease%20inhibitor n8:HIV-1%20protease n8:X-ray%20structural%20analysis n8:darunavir
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6BDCEE92438B]
n3:nazevZdroje
Journal of Virology
n3:obor
n13:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n16:1M0508
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
83
n3:tvurceVysledku
Brynda, Jiří Řezáčová, Pavlína Grantz Šašková, Klára Yashina, T. Kagan, R. M. Konvalinka, Jan Kožíšek, Milan
n3:wos
000269122300048
n3:zamer
n7:AV0Z50520514 n7:AV0Z40550506
s:issn
0022-538X
s:numberOfPages
9