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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F08%3A00306790%21RIV09-AV0-68378050
rdf:type
n3:Vysledek skos:Concept
dcterms:description
U léčených myší byla detekována zvýšená produkce cytokinů, ale nebyl nalezen rozdíl v Th1/Th2 polarizaci imunitní odpovědi. Ve slezinách myší nesoucích TC-1 (MHC I+), ale ne TC-1/A9 (MHC I–) nádory, byly nalezeny cytotoxické CD8+ buňky. Ve slezinách léčených myší nesoucích TC-1/A9 nádory, byly naopak nalezena NK aktivita detekovatelná jako lýza NK senzitivních YAC-1 buněk. Snížený počet CD4+ a CD8+ buněk přetrvával I po léčbě; zatím co procento CD25+/CD4+ T regulačních buněk se neměnilo. Chemoterapie vedla ke zvýšení počtu imunosupresivních nezralých myeloidních buněk Gr-1+/CD11b+ (IMC) ve slezinách léčených zvířat. Jejich akumulace by mohla být zodpověná za zvýšení imunitní odpověďi po adjuvantní léčbě pomocí IL-12. In this model, upregulation of cytokine production was detected, compared to the animals without tumours. But, no differences in Th1/Th2 polarization of the immune responses were observed. In the spleens of TC-1 (MHC class I+) but not of TC-1/A9 (MHC class I–) treated tumour-bearing animals, the cytotoxic CD8+ cells were found. In the spleens of TC-1/A9 but not of TC-1 tumour-treated animals, the NK activity measured as the lysis of NK-sensitive YAC-1 targets was detected. Downregulation of the CD4+ and CD8+ subpopulations were not restored after therapy. The percentage of CD25+/CD4+ T regulatory cells in lymph nodes remained unchanged. The chemotherapy led to upregulation of immunosuppressive immature myeloid Gr-1+/CD11b+ (IMC) cells in the spleens of treated animals. The accumulation of IMC was significantly decreased after subsequent IL-12 immunotherapy. That elimination may be responsible for the improvement of antitumour responses after adjuvant IL-12 vaccination. In this model, upregulation of cytokine production was detected, compared to the animals without tumours. But, no differences in Th1/Th2 polarization of the immune responses were observed. In the spleens of TC-1 (MHC class I+) but not of TC-1/A9 (MHC class I–) treated tumour-bearing animals, the cytotoxic CD8+ cells were found. In the spleens of TC-1/A9 but not of TC-1 tumour-treated animals, the NK activity measured as the lysis of NK-sensitive YAC-1 targets was detected. Downregulation of the CD4+ and CD8+ subpopulations were not restored after therapy. The percentage of CD25+/CD4+ T regulatory cells in lymph nodes remained unchanged. The chemotherapy led to upregulation of immunosuppressive immature myeloid Gr-1+/CD11b+ (IMC) cells in the spleens of treated animals. The accumulation of IMC was significantly decreased after subsequent IL-12 immunotherapy. That elimination may be responsible for the improvement of antitumour responses after adjuvant IL-12 vaccination.
dcterms:title
IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets Imunoterapie minimální zbytkové choroby interleukinem 12 na myším modelu nádorů asociovaných s virem HPV 16: Indukce imunitní odpovědi, produkce cytokinů a kinetika subpopulací imunních buněk IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets
skos:prefLabel
Imunoterapie minimální zbytkové choroby interleukinem 12 na myším modelu nádorů asociovaných s virem HPV 16: Indukce imunitní odpovědi, produkce cytokinů a kinetika subpopulací imunních buněk IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets IL-12 immunotherapy of minimal residual disease in murine models of HPV16-associated tumours: induction of immune responses, cytokine production and kinetics of immune cell subsets
skos:notation
RIV/68378050:_____/08:00306790!RIV09-AV0-68378050
n5:aktivita
n10:Z n10:P
n5:aktivity
P(GA301/06/0774), Z(AV0Z50520514)
n5:cisloPeriodika
2
n5:dodaniDat
n7:2009
n5:domaciTvurceVysledku
n9:9414185 n9:4531140 n9:4251954 n9:6215319
n5:druhVysledku
n11:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
371396
n5:idVysledku
RIV/68378050:_____/08:00306790
n5:jazykVysledku
n14:eng
n5:klicovaSlova
HPV 16; MHC class I-positive and -deficient tumours; immature myeloid cells
n5:klicoveSlovo
n13:immature%20myeloid%20cells n13:MHC%20class%20I-positive%20and%20-deficient%20tumours n13:HPV%2016
n5:kodStatuVydavatele
GR - Řecká republika
n5:kontrolniKodProRIV
[AA8B92957B40]
n5:nazevZdroje
International Journal of Oncology
n5:obor
n12:EB
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
4
n5:projekt
n6:GA301%2F06%2F0774
n5:rokUplatneniVysledku
n7:2008
n5:svazekPeriodika
32
n5:tvurceVysledku
Bieblová, Jana Bubeník, Jan Indrová, Marie Reiniš, Milan
n5:wos
000252620900025
n5:zamer
n17:AV0Z50520514
s:issn
1019-6439
s:numberOfPages
9