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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F08%3A00097944%21RIV08-AV0-68378050
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Článek obsahuje osobní pohled autora na vědeckou a společenskou atmosféru bývalého Československa. Zabývá se obdobím vzestupu Haškovy imunologické školy a aplikací imunologické tolerance na hetero-přenos viru Rousova sarkomu (RSV). To umožnilo vytvořit nový model savčích buněk transformovaných RSV (virogenních XC buněk), kde neinfekční virový genom je přítomen jako nová genetická informace (provirus). RSV bylo však možno získat ze savčích nepermisivních buněk jejich fúzí s permisivními kuřecími fibroblasty. To otevřelo cestu k porozumění nepermisivity vůči retrovirové infekci. This chapter provides a personal insight into the scientific and social atmosphere in former Czechoslovakia. It covers the period of the rise of Hašek’s immunologic school and application of immunologic tolerance to Rous sarcoma virus (RSV) heterotransmission. These approaches permitted establishment of a new model of mammalian cells transformed by RSV (virogenic XC cells), where the noninfectious viral genome was kept indefinitely as new genetic information (provirus). RSV was rescued from nonpermissive mammalian cells by fusion (complementation) with permissive chicken fibroblasts; this opened the way to understanding virus nonpermissiveness. This chapter provides a personal insight into the scientific and social atmosphere in former Czechoslovakia. It covers the period of the rise of Hašek’s immunologic school and application of immunologic tolerance to Rous sarcoma virus (RSV) heterotransmission. These approaches permitted establishment of a new model of mammalian cells transformed by RSV (virogenic XC cells), where the noninfectious viral genome was kept indefinitely as new genetic information (provirus). RSV was rescued from nonpermissive mammalian cells by fusion (complementation) with permissive chicken fibroblasts; this opened the way to understanding virus nonpermissiveness.
dcterms:title
Twists and turns in life and science. Foundation Series in Cancer Research Klikaté cesty života a vědy. Zakladatelská série výzkumu rakoviny Twists and turns in life and science. Foundation Series in Cancer Research
skos:prefLabel
Twists and turns in life and science. Foundation Series in Cancer Research Twists and turns in life and science. Foundation Series in Cancer Research Klikaté cesty života a vědy. Zakladatelská série výzkumu rakoviny
skos:notation
RIV/68378050:_____/08:00097944!RIV08-AV0-68378050
n3:strany
1;32
n3:aktivita
n17:Z
n3:aktivity
Z(AV0Z50520514), Z(AV0Z5052915)
n3:cisloPeriodika
1
n3:dodaniDat
n9:2008
n3:domaciTvurceVysledku
n10:4364090
n3:druhVysledku
n13:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
400928
n3:idVysledku
RIV/68378050:_____/08:00097944
n3:jazykVysledku
n14:eng
n3:klicovaSlova
cancer; oncogene; src
n3:klicoveSlovo
n7:cancer n7:src n7:oncogene
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[21EFE032EAAC]
n3:nazevZdroje
Advances in Cancer Research
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n9:2008
n3:svazekPeriodika
99
n3:tvurceVysledku
Svoboda, Jan
n3:zamer
n11:AV0Z5052915 n11:AV0Z50520514
s:issn
0065-230X
s:numberOfPages
32