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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F07%3A00097943%21RIV08-AV0-68378050
rdf:type
skos:Concept n11:Vysledek
dcterms:description
The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis. The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis. Chemokinový receptor CCR2 je vysoce exprimován na monocytech a zdá se být slibným terčem pro léčbu reumatické arthritidy. Blokování CCR2 monoklonální protilátkou při arthritidě vyvolané kolagenem však vede k masivnímu zhoršení této choroby. V této studii jsme sledovali, proč protilátky CCR2+ mají prozánětlivé účinky, jak se těmto účinkům lze vyhnout a zda jsou monocyty CCR2+ dobrými terči pro léčbu arthritidy.
dcterms:title
Cílení Gr-1+,CCR2+ monocytů u arthritidy vyvolané kolagenem Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis
skos:prefLabel
Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis Cílení Gr-1+,CCR2+ monocytů u arthritidy vyvolané kolagenem Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis
skos:notation
RIV/68378050:_____/07:00097943!RIV08-AV0-68378050
n3:strany
2975;2985
n3:aktivita
n10:Z
n3:aktivity
Z(AV0Z50520514)
n3:cisloPeriodika
9
n3:dodaniDat
n14:2008
n3:domaciTvurceVysledku
n8:1420275
n3:druhVysledku
n13:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
454163
n3:idVysledku
RIV/68378050:_____/07:00097943
n3:jazykVysledku
n17:eng
n3:klicovaSlova
arthritis; CCR2; monocytes
n3:klicoveSlovo
n6:CCR2 n6:monocytes n6:arthritis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6DD9F0D9FB88]
n3:nazevZdroje
Arthritis and Rheumatism
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n14:2007
n3:svazekPeriodika
56
n3:tvurceVysledku
Denzel, A. Mack, M. Plachý, Jiří Niedermeier, M. Brühl, H. Kunz-Schughart, L. Cihak, J. Gomez, M. R. Talke, Y. Stangassinger, M. Luckow, B.
n3:zamer
n16:AV0Z50520514
s:issn
0004-3591
s:numberOfPages
11