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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F07%3A00094603%21RIV08-AV0-68378050
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Popisujeme pax-six-eyes absent-dachshund síť (psedn) u kopinatce. Všeobecně se interakce mezi geny a proteiny ze sítě podobají těm z jiných zvířat, s výjimkou absencí dach-eya vazby. Geny psedn se projevují ve vysoce specifických vzorcích zejména v gastrule, notochordu, somitech, centrální nervové soustavy, okrajové nervové soustavy, pharyngealním entodermu. Konzervace psedn může odrážet nepostradatelnou angažovanost genů psedns během kriticky důležité rané fáze embryonálního vývoje. Drosophila retinal determination gene network in animals is generally Pax-Six-Eyes absent-Dachshund (PSEDN). We describe complete amphioxus network of 9 PSEDN genes, 4 of which are characterized here for the first time. In vitro interactions among the genes and proteins of amphioxus network resemble those of other animals except for Dach-Eya binding absence. Amphioxus PSEDN genes are expressed in highly stage- and tissue-specific patterns in the gastrular organizer, notochord, somites, anterior central nervous system, peripheral nervous system, pharyngeal endoderm and the likely homolog of vertebrate adenohypophysis, whose anterior region expresses all amphioxus Six genes and is cell proliferation-active, while the posterior one expresses only AmphiPax6 and is non-proliferative. Topologies of animal PSEDNs, though much more variable than supposed, arethus conserved among species and developing tissues; PSEDNs thus play a key role in critically important early phases of embryology. Drosophila retinal determination gene network in animals is generally Pax-Six-Eyes absent-Dachshund (PSEDN). We describe complete amphioxus network of 9 PSEDN genes, 4 of which are characterized here for the first time. In vitro interactions among the genes and proteins of amphioxus network resemble those of other animals except for Dach-Eya binding absence. Amphioxus PSEDN genes are expressed in highly stage- and tissue-specific patterns in the gastrular organizer, notochord, somites, anterior central nervous system, peripheral nervous system, pharyngeal endoderm and the likely homolog of vertebrate adenohypophysis, whose anterior region expresses all amphioxus Six genes and is cell proliferation-active, while the posterior one expresses only AmphiPax6 and is non-proliferative. Topologies of animal PSEDNs, though much more variable than supposed, arethus conserved among species and developing tissues; PSEDNs thus play a key role in critically important early phases of embryology.
dcterms:title
Síť Pax-Six-Eya-Dach ve vývoji kopinatce: konzervace in vitro ale kontextová specifita in vivo Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo
skos:prefLabel
Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo Síť Pax-Six-Eya-Dach ve vývoji kopinatce: konzervace in vitro ale kontextová specifita in vivo
skos:notation
RIV/68378050:_____/07:00094603!RIV08-AV0-68378050
n3:strany
143;159
n3:aktivita
n4:Z n4:P
n3:aktivity
P(IAA500520604), Z(AV0Z50520514)
n3:cisloPeriodika
1
n3:dodaniDat
n5:2008
n3:domaciTvurceVysledku
n7:6641946 n7:1198556 n7:6733654
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
440850
n3:idVysledku
RIV/68378050:_____/07:00094603
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Pax; gene; evolution
n3:klicoveSlovo
n6:evolution n6:gene n6:Pax
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0314C4F72F61]
n3:nazevZdroje
Developmental Biology
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
10
n3:projekt
n17:IAA500520604
n3:rokUplatneniVysledku
n5:2007
n3:svazekPeriodika
306
n3:tvurceVysledku
Benes, V. Jonášová, Kristýna Kozmik, Zbyněk Schubert, M. Pestarino, M. Krešlová, Jana Olivery, D. Holland, L. Z. Candiani, S. Holland, N. D.
n3:zamer
n14:AV0Z50520514
s:issn
0012-1606
s:numberOfPages
17