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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F06%3A00047784%21RIV07-MSM-68378050
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Alfa-tokoferol sukcinát (vitamin E sukcinát, a-TOS) zvyšuje citlivost mesotheliomálních nádorových buněk k apoptóze indukované cytotoxickým ligandem TRAIL. a-TOS zvyšuje expresi proapoptotických TRAILových receptorů DR4/DR5 v závislosti na p53. Mesotheliomální buňky rezistentní k TRAILu mají nízkou expresi DR4/DR5, kterou lze zvýšit předinkubací se subletálními dávkami a-TOS. We evaluated the ability of alpha-tocopheryl succinate (a-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that alpha-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishes sensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal doses of a-TOS restored expression of DR4 and DR5. The ability of a-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli. We evaluated the ability of alpha-tocopheryl succinate (a-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that alpha-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishes sensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal doses of a-TOS restored expression of DR4 and DR5. The ability of a-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli.
dcterms:title
Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis Alfa-tokoferol sukcinát vyvolává expresi DR4 a DR5 cestou závislou na p53: implikace pro sensitizaci rezistentních nádorových buněk k apoptóze vyvolané prostřednictvím TRAIL
skos:prefLabel
Alfa-tokoferol sukcinát vyvolává expresi DR4 a DR5 cestou závislou na p53: implikace pro sensitizaci rezistentních nádorových buněk k apoptóze vyvolané prostřednictvím TRAIL Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis
skos:notation
RIV/68378050:_____/06:00047784!RIV07-MSM-68378050
n4:strany
1925;1931
n4:aktivita
n5:Z n5:P
n4:aktivity
P(IAA5052001), P(LN00A026), Z(AV0Z50520514)
n4:cisloPeriodika
8
n4:dodaniDat
n13:2007
n4:domaciTvurceVysledku
n9:9022643 n9:4589874
n4:druhVysledku
n11:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
464630
n4:idVysledku
RIV/68378050:_____/06:00047784
n4:jazykVysledku
n17:eng
n4:klicovaSlova
malignant mesothelioma; TRAIL; alpha-TOS
n4:klicoveSlovo
n16:alpha-TOS n16:TRAIL n16:malignant%20mesothelioma
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[4EA7E8345171]
n4:nazevZdroje
FEBS Letters
n4:obor
n15:EB
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
6
n4:projekt
n12:LN00A026 n12:IAA5052001
n4:rokUplatneniVysledku
n13:2006
n4:svazekPeriodika
580
n4:tvurceVysledku
Borghi, B. Neužil, Jiří Alleva, R. Anděra, Ladislav Procopio, A. Tomasetti, M.
n4:zamer
n14:AV0Z50520514
s:issn
0014-5793
s:numberOfPages
7