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Statements

Subject Item
n2:RIV%2F68378050%3A_____%2F06%3A00047757%21RIV07-MZ0-68378050
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The effect of 13 flavonoid derivatives on paclitaxel transport was investigated in two human breast cancer cell lines, adriamycin-sensitive and adriamycin-resistant. Some derivatives proved to be efficient modulators of paclitaxel transport in P-gp highly expressing resistant human breast cancer cells. They also were more efficient than natural flavonoids. These agents could increase the efficiency of chemotherapy with paclitaxel in such resistant cells. However, care should be taken of the fact that drug transport in the P-gp non-expressing tumors may be influenced quite differently due to other transporters. Further studies are needed to investigate whether these derivatives are sufficiently potent to increase the effect of P-gp transported anticancer drugs in vivo. The effect of 13 flavonoid derivatives on paclitaxel transport was investigated in two human breast cancer cell lines, adriamycin-sensitive and adriamycin-resistant. Some derivatives proved to be efficient modulators of paclitaxel transport in P-gp highly expressing resistant human breast cancer cells. They also were more efficient than natural flavonoids. These agents could increase the efficiency of chemotherapy with paclitaxel in such resistant cells. However, care should be taken of the fact that drug transport in the P-gp non-expressing tumors may be influenced quite differently due to other transporters. Further studies are needed to investigate whether these derivatives are sufficiently potent to increase the effect of P-gp transported anticancer drugs in vivo. Účinek 13 flavonoidových derivátů byl zkoumán u dvou buněčných linií lidského nádoru prsu odolných vůči adriamycinu a cilivých na tuto látku. Některé tyto deriváty napomáhaly transportu paxlitaxelu v rezistentních buňkách vysoce exprimujících P-gp. Byly také účinnější než přirozené flavonoidy. Tyto látky by mohly účinně napomáhat chemoterapii paclitaxelem u těchto rezistentních buněk. Je však třeba vzít v úvahu, že transport terapeutických látek v buňkách neexprimujících P-gp může být odlišný díky vlivu dalších přenašečů. Ke zjištění, zda tyto deriváty mají dostatečný vliv na zvýšení účinku protinádorových látek přenášených P-gp in vivo, je třeba dalších studií.
dcterms:title
Modulace transportu paclitaxelu flavonoidovými deriváty v buňkách lidského nádoru prsu. Existuje vztah mezi vazebnou afinitou k NBD P-gp a modulací transportu? Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?
skos:prefLabel
Modulace transportu paclitaxelu flavonoidovými deriváty v buňkách lidského nádoru prsu. Existuje vztah mezi vazebnou afinitou k NBD P-gp a modulací transportu? Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?
skos:notation
RIV/68378050:_____/06:00047757!RIV07-MZ0-68378050
n3:strany
4519;4525
n3:aktivita
n14:Z n14:P
n3:aktivity
P(GA305/04/0403), P(NL7567), Z(AV0Z50520514)
n3:cisloPeriodika
13
n3:dodaniDat
n6:2007
n3:domaciTvurceVysledku
n12:7020597 n12:1758330
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
486568
n3:idVysledku
RIV/68378050:_____/06:00047757
n3:jazykVysledku
n7:eng
n3:klicovaSlova
paclitaxel; multidrug resistance; flavonoid derivatives
n3:klicoveSlovo
n5:multidrug%20resistance n5:flavonoid%20derivatives n5:paclitaxel
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0C4958A10C66]
n3:nazevZdroje
Bioorganic and Medicinal Chemistry Letters
n3:obor
n4:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n11:GA305%2F04%2F0403 n11:NL7567
n3:rokUplatneniVysledku
n6:2006
n3:svazekPeriodika
14
n3:tvurceVysledku
Gut, I. Václavíková, R. Boumendjel, A. Ehrlichová, Marie Kovář, Jan
n3:zamer
n16:AV0Z50520514
s:issn
0960-894X
s:numberOfPages
7